PMID: 7547191Apr 1, 1995Paper

In vivo 31P MRS: absolute concentrations, signal-to-noise and prior knowledge

NMR in Biomedicine
A Van den BoogaartJ R Griffiths

Abstract

Absolute metabolite concentrations have been estimated for nucleoside triphosphate and P(i) from in vivo 31P MR measurements using ISIS localization in a rat tumour model, and the results have been compared to those obtained from acid extracts of the tumours. The aim of the experiment was to assess the performance of four different spectral analysis techniques used for absolute quantitation. The spectral analysis techniques used were two frequency domain methods (peak area integration and Lorentzian fitting--FITSPEC) and two time domain methods (VARPRO and HLSVD). The spectra were acquired in blocks so that the degradation in performance of the four spectral analysis methods with decreasing signal-to-noise ratio (SNR) could be compared and referenced. This and the inclusion of a sophisticated method incorporating prior knowledge yields a more realistic and comprehensive protocol than previously published comparisons. The results suggest that VARPRO is the method of choice for quantitative analysis of tumour 31P MR spectra, giving the most reliable results at low SNR.

References

Sep 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J E van DijkW M Bovée
Nov 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D C ShunguJ D Glickson
Nov 1, 1992·NMR in Biomedicine·M StubbsJ R Griffiths
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A R Mazzeo, G C Levy
Oct 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y HiltunenY A Kesäniemi
Apr 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M JoliotR H Huesman
Jul 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P R LuytenJ A den Hollander
Jan 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J W van der VeenD van Ormondt
Nov 1, 1993·NMR in Biomedicine·J D de CertainesO Henriksen
Apr 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A van den BoogaartJ R Griffiths
Nov 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Buchli, P Boesiger

❮ Previous
Next ❯

Citations

Jan 5, 2002·European Journal of Pharmacology·Roger J LegtenbergPaul Smits
Jan 22, 2000·Molecular Aspects of Medicine·C Boesch
Mar 22, 2003·European Journal of Radiology·Yoshitaka MasutaniKuni Otomo
Jun 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y J KammD J Wagener
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·G WalterH L Sweeney
Jun 19, 2001·NMR in Biomedicine·S Mierisová, M Ala-Korpela
Jul 17, 2004·Neoplasia : an International Journal for Oncology Research·Vassiliki KostourouSimon P Robinson
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·S P RobinsonM Stubbs
Oct 3, 2008·Journal of Magnetic Resonance·Jean-Baptiste PoulletSabine Van Huffel
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Clemens ElsterHerbert Rinneberg
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Aug 1, 1996·NMR in Biomedicine·H J LambA de Roos
Jan 5, 2002·AJR. American Journal of Roentgenology·Elias R MelhemPeter C M van Zijl
Dec 8, 2019·Pediatric Research·James R C ParkinsonNeena Modi
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S HitchinsG P Dobson
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lesley D McPhailSimon P Robinson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.