In vivo 3D human vocal fold imaging with polarization sensitive optical coherence tomography and a MEMS scanning catheter.

Optics Express
Ki Hean KimJohannes F de Boer

Abstract

We present in-vivo 3D human vocal fold images with polarization sensitive optical coherence tomography (PS-OCT). Characterizing the extent and location of vocal fold lesions provides useful information in guiding surgeons during phonomicrosurgery. Previous studies showed that PS-OCT imaging can distinguish vocal fold lesions from normal tissue, but these studies were limited to 2D cross-sectional imaging and were susceptible to sampling error. In-vivo 3D endoscopic imaging was performed by using a recently developed 2-axis MEMS scanning catheter and a spectral domain OCT (SD-OCT), running at 18.5 frames/s. Imaging was performed in the operating room with patients under general anesthesia and 3D images were acquired either by 2D scanning of the scanner on the sites of interest or by combining 1D scanning and manual sliding to capture whole length of the vocal fold. Vocal fold scar, polyps, nodules, papilloma and malignant lesions were imaged and characteristics of individual lesions were analyzed in terms of spatial distribution and variation of tissue structure and birefringence. The 3D large sectional PS-OCT imaging showed that the spatial extent of vocal fold lesions can be found non-invasively with good contrast from normal ...Continue Reading

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Citations

Jan 17, 2013·American Journal of Respiratory and Critical Care Medicine·Lida P HaririMelissa J Suter
Jan 10, 2012·Annals of Biomedical Engineering·Athanasios SarantopoulosVasilis Ntziachristos
May 13, 2011·Analytical and Bioanalytical Chemistry·Julia WaltherEdmund Koch
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Dec 12, 2018·Archives of Pathology & Laboratory Medicine·Wendy A WellsLida P Hariri
Dec 18, 2012·Biomedical Optics Express·Ramona CernatAdrian Gh Podoleanu
Mar 18, 2015·Biomedical Optics Express·Jacob C M LowKonstantina M Stankovic
Jul 1, 2017·Biomedical Optics Express·Michalina J GoraXingde Li
Apr 23, 2013·Journal of Biophotonics·Ryan L SheltonStephen A Boppart
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Jan 26, 2011·Optics Express·Ki Hean KimJohannes F de Boer
Aug 24, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·James A Burns
Jan 27, 2019·Lasers in Surgery and Medicine·Tiffany T PhamBrian J F Wong
Jun 9, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lida P HaririMelissa J Suter

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Methods Mentioned

BETA
imaging technique
biopsy

Software Mentioned

OCT
PS

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