In vivo 4.0-T magnetic resonance investigation of spinal cord inflammation, demyelination, and axonal damage in chronic-progressive experimental allergic encephalomyelitis

Journal of Magnetic Resonance Imaging : JMRI
Lisa L CookS J Karlik

Abstract

To image and dissect the lumbar spinal cord of guinea pigs with chronic-progressive experimental allergic encephalomyelitis (CP-EAE) and directly correlate the pathology to the magnetic resonance (MR) image data obtained at 4 T and determine if these MR contrasts can accurately differentiate a specific type of pathology from control tissue. The amount of inflammation, demyelination, and axonal pathology were quantified in the whole cord cross sections. The signal intensities (SIs) for 228 individual regions of interest (ROIs) (normal-appearing white matter (NAWM) and tissue containing inflammation with or without demyelination) were measured directly from the corresponding area on the MR images. Conventional MR contrast SIs and magnetization transfer ratio (MTR) were related to the degree of demyelination and presence of inflammation. MTR and proton density-weighted (PDw) SIs were both moderately related to axonal density. The SIs for NAWM and in lesions containing both cellular infiltrates and demyelination in all conventional MR contrast images were also increased, whereas the MTR was decreased when compared to control tissue. The SIs from the conventional MR contrasts and MTR at 4 T were sensitive to the presence of disease ...Continue Reading

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Citations

Nov 22, 2005·Neurobiology of Disease·Joong Hee KimSheng-Kwei Song
Jan 18, 2011·NeuroImage·Eric C KlawiterTammie L Benzinger
Mar 7, 2015·Neurochemistry International·Sveinung FjærStig Wergeland
Mar 26, 2015·PloS One·Irmhild Altmann-SchneiderJeroen van der Grond
Mar 29, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew D BuddeSheng-Kwei Song
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mark A Horsfield
Sep 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gian Franco PireddaTobias Kober
Jul 16, 2005·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M K ErskineS J Karlik
Dec 16, 2005·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Maria-Benedicta EdwardsIan R Young
Oct 31, 2017·Developmental Neurobiology·Florence HeathCassandra Sampaio-Baptista

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