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In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia

Circulation

Nov 30, 2019

Huan ZhaoBin Zhou

Abstract

Background: Mutations in low-density lipoprotein receptor (LDLR) are one of the main causes of familial hypercholesterolemia (FH), which induces atherosclerosis and has a high lifetime risk of cardiovascular disease. The clustered regularly interspaced short palindromic repeats (CRISPR)...read more

Mentioned in this Paper

In Vivo
AAVS1
LDLR
Plaque, Atherosclerotic
Genes
CRISPR-Cas Systems
Gene Editing
Hypercholesterolemia, Familial
Gene Mutation
Maintenance of Crispr Repeat Elements
7
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In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia

Circulation

Nov 30, 2019

Huan ZhaoBin Zhou

PMID: 31779484

DOI: 10.1161/circulationaha.119.042476

Abstract

Background: Mutations in low-density lipoprotein receptor (LDLR) are one of the main causes of familial hypercholesterolemia (FH), which induces atherosclerosis and has a high lifetime risk of cardiovascular disease. The clustered regularly interspaced short palindromic repeats (CRISPR)...read more

Mentioned in this Paper

In Vivo
AAVS1
LDLR
Plaque, Atherosclerotic
Genes
CRISPR-Cas Systems
Gene Editing
Hypercholesterolemia, Familial
Gene Mutation
Maintenance of Crispr Repeat Elements
7

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Paper Details
References
  • References43
  • Citations
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  • References43
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