In vivo activation of zoxazolamine metabolism by flavone

Science
J M LaskerAllan H Conney

Abstract

The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate several-fold stimulation in the rate of total body metabolism of simultaneously administered zoxazolamine. This is the first demonstration of stimulation of oxidative drug metabolism in vivo by a zenobiotic that is an activator of hepatic microsomal.

Citations

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Related Concepts

Metazoa
Cytochrome P-450 Oxygenase
Drug Combinations
Drug Interactions
Bioflavonoids
Hydroxylation
Microsomes, Liver
Zoxazolamine
Rats, Laboratory

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