In vivo acute treatment with trimethyltin chloride causes neuronal degeneration in the murine olfactory bulb and anterior olfactory nucleus by different cascades in each region

Journal of Neuroscience Research
Koichi KawadaKiyokazu Ogita

Abstract

Our earlier study demonstrated that in vivo acute treatment with trimethyltin chloride (TMT) produces severe neuronal damage in the dentate gyrus and cognition impairment in mice. In the present study, we assessed whether TMT was capable of causing neuronal degeneration in the olfactory bulb (OB) and anterior olfactory nucleus (AON) of the mouse brain. An intraperitoneal injection of TMT at the dose of 2.8 mg/kg led to a dramatic increase in the number of degenerating cells, which were reactive with antibody against single-stranded DNA, in the granule cell layer (GCL) of the OB and AON 1 day and 2 days later, respectively. TMT treatment produced a marked translocation of phospho-c-Jun-N-terminal kinase from the cytoplasm to the nucleus in the AON. Expectedly, a marked increase in phospho-c-Jun-positive cells was seen in the AON after the treatment. In addition to the AON, the mitral cell layer of the olfactory bulb showed the presence of phospho-c-Jun-positive cells after the treatment. However, the GCL had no cells positive for either phospho-c-Jun-N-terminal kinase or phospho-c-Jun at any time after the treatment with TMT. Similarly, TMT-induced nuclear translocation of the lysosomal enzyme deoxyribonuclease II was seen in th...Continue Reading

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Citations

Oct 16, 2015·Neurotoxicology·Cinzia FabriziLorenzo Fumagalli
Dec 10, 2009·Journal of Neuroscience Research·Masanori YoneyamaKiyokazu Ogita
Nov 6, 2012·Biological & Pharmaceutical Bulletin·Yaichiro Kotake
Jun 22, 2010·Journal of Pharmacological Sciences·Reiko NagashimaKiyokazu Ogita
Aug 2, 2019·Biological & Pharmaceutical Bulletin·Hang Thi Nguyet PhamKinzo Matsumoto
Oct 3, 2014·Biological & Pharmaceutical Bulletin·Masanori YoneyamaKiyokazu Ogita
Aug 7, 2009·Chemical Research in Toxicology·Jiali CaiZhenghong Zuo
Apr 18, 2014·ACS Chemical Neuroscience·Yumiko MotoiNobutaka Hattori

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