PMID: 9536432Apr 16, 1998Paper

In vivo alteration in type-1 and type-2 cytokine balance: a possible mechanism for elevated total IgE in HIV-infected patients

Human Immunology
S K Agarwal, G D Marshall

Abstract

The progression of HIV infection has been associated with an increase in the plasma levels of total IgE. The mechanisms responsible for the increased IgE have not been elucidated. The type-1 and type-2 cytokine imbalance associated with HIV infection has been proposed as a possible mechanism for elevated IgE. The current study was undertaken to investigate the relationship between total IgE, type-1 and type-2 cytokines from a large HIV+ patient population. HIV+ patients were found to have elevated total IgE that inversely correlated with numbers of CD4+ T-cells. HIV+ plasma was also found to have decreased IFN-gamma and IL-12p70 levels as well as increased IL-10 levels compared to HIV-negative individuals. HIV+ patients with more advanced disease, as defined by absolute CD4+ counts, demonstrated more marked differences. Furthermore, the relative ratios of IFN-gamma:IL-10 and IL-12:IL-10 were decreased in HIV+ patients compared to HIV-negative individuals. The alterations in the plasma cytokines suggest a switch from a predominance of type-1 cytokines to type-2 cytokines that may enhance IgE synthesis. These data suggest that measurement of plasma IgE and/or cytokines may have prognostic or therapeutic monitoring value in HIV+ p...Continue Reading

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Citations

Jun 5, 2002·Current Allergy and Asthma Reports·Donald Rudikoff
Oct 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S K Agarwal, G D Marshall
Nov 30, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S K Agarwal, G D Marshall
Jan 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S K Agarwal, G D Marshall
Nov 15, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Heather J ZarGregory Hussey
Jan 12, 2000·The Journal of Allergy and Clinical Immunology·S K Agarwal, G D Marshall
Feb 13, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S K Agarwal, G D Marshall
Mar 3, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aicha AbbasJean-François Zagury
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M LedochowskiD Fuchs
Aug 8, 2002·The Korean Journal of Internal Medicine·Jee Hyun ParkNung Soo Kim
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·D S HardinD K Seilheimer
Jul 5, 2002·Brain, Behavior, and Immunity·Virginia M Sanders, Rainer H Straub
Mar 19, 1999·Brain, Behavior, and Immunity·G D MarshallG J Morris

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