In vivo alterations in cytokine production following interleukin-12 (IL-12) and anti-IL-4 antibody treatment of CB6F1 mice with chronic cutaneous leishmaniasis.

Infection and Immunity
J LiJ P Farrell

Abstract

CB6F1 mice exhibit intermediate resistance to infection with Leishmania major compared to their highly susceptible (BALB/c) and resistant (C57BL/6) parental strains. Unlike the C57BL/6 and BALB/c strains, which rapidly develop dominant Th1- or Th2-type responses, respectively, after infection, CB6F1 mice develop responses in which both Th1- and Th2-type cytokines are elevated through at least the first month of infection before Th1 responses become dominant as cutaneous lesions gradually heal. We have examined the effects of interleukin-12 (IL-12) and/or anti-IL-4 antibody treatment on cytokine production and the course of disease in CB6F1 mice with chronic L. major infections. When administered at 1 month of infection, IL-12 treatment led to a rapid decrease in mRNA levels for IL-4 within parasitized lesions and a moderate increase in gamma interferon (IFN-gamma) transcript levels in lymph nodes draining the site of infection. When IL-12 and anti-IL-4 antibody were administered together, they induced a marked decrease in IL-4 and transforming growth factor beta mRNA expression within lesions and a more dramatic increase in lymph node IFN-gamma transcript levels within 4 days after treatment. In comparison, similar treatment of...Continue Reading

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Citations

Dec 12, 2001·Parasite Immunology·L M BagenstoseM Monestier
Sep 13, 2006·Parasite Immunology·E M CarvalhoM I Araújo
Jun 17, 1998·Scandinavian Journal of Immunology·C M Lezama-DávilaR Chapa-Ruiz
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Jan 2, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Masoud Foroutan-RadShahram Khademvatan
Mar 21, 2006·ILAR Journal·Craig L Franklin
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Udaikumar M PadigelJay P Farrell

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