In vivo analysis of a superantigen-induced T cell suppressor factor

Cellular Immunology
H L HuY S Lin

Abstract

We have previously reported that the superantigen staphylococcal enterotoxin B (SEB) was able to suppress an immune response to sheep red blood cells when administered intravenously to mice. While the capacity of the superantigens to stimulate lymphocytes and accessory cell functions has been thoroughly examined, it is clear that these agents may also exhibit potent immunosuppressive activity both in vivo and in vitro. This SEB-induced immunosuppression was determined by our laboratories to be mediated by a population of T suppressor cells. The suppression may be due to the generation of inhibitory lymphokines, including IL-10 or transforming growth factor beta, following superantigen stimulation. Alternatively, the immunomodulatory activity may be due to the activation of antigen-specific and/or genetically restricted suppressor cells by SEB. The mechanism of activity of these suppressor cells has not been fully defined. In this report we wished to determine whether a suppressor factor generated from SEB-activated T cells in vitro may be responsible for the inhibition of antibody or delayed-type hypersensitivity responses in vivo. We observed that both antibody and delayed-type hypersensitivity responses were inhibited followi...Continue Reading

Citations

Feb 9, 2012·Journal of the Association for Research in Otolaryngology : JARO·Heather K LehmanRichard B Bankert
Mar 4, 2009·Infection and Immunity·Damien ThomasGerard Lina
Apr 18, 2020·Immunological Investigations·Gautam N ShenoyRichard B Bankert
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S JarraudG Lina
Mar 26, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tatsuo YamamotoDa Shi

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