In vivo analysis of choroidal vascularity index changes in eyes with Fuchs uveitis syndrome.

Photodiagnosis and Photodynamic Therapy
Alev Ozcelik-KoseEce Turan-Vural

Abstract

This study aimed to investigate changes in the choroidal vascularity index (CVI) in eyes with Fuchs uveitis syndrome (FUS) and determine the effect of heterochromia on choroidal vascularity using binarisation of enhanced-depth imaging (EDI)-optical coherence tomography (OCT) images. The study included the affected eyes (FEs) and unaffected fellow eyes (NFEs) of 24 patients with unilateral FUS and the eyes of 30 healthy controls (HCs). The subfoveal total choroidal area (TCA) and the luminal area (LA) were determined by binarised EDI-OCT images using Image J software (National Institutes of Health, Bethesda, MD). The CVI value was calculated by dividing the LA value by the TCA value. The CVI values were significantly lower in FEs (58.8 ± 3.7 %) compared to NFEs (62.3 ± 3.9 %, p = 0.002) and HCs (61.1 ± 3.7 %, p = 0.008). The mean LA was significantly narrower in FEs than in NFEs (p = 0.047) and HCs (p = 0.001). Additionally, the mean CVI values were significantly lower in eyes with heterochromia compared to those without heterochromia (p = 0.024) in the affected eyes of patients with FUS. This study shows that there are significant quantitative structural changes, especially in the luminal part of the subfoveal choroid, in eyes ...Continue Reading

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Citations

Aug 28, 2021·Photodiagnosis and Photodynamic Therapy·Mevlüt YılmazTaha Ayyıldız

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