In vivo and in vitro bisphenol A exposure effects on adiposity.

Journal of Developmental Origins of Health and Disease
M DesaiM G Ross

Abstract

In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As adipogenesis is a critical factor contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn adipose tissue at the stem-cell level. For in vivo studies, female rats received BPA before and during pregnancy and lactation via drinking water, and offspring were studied for measures of adiposity signals. For in vitro BPA exposure, primary pre-adipocyte cell cultures from healthy newborns were utilized. We studied pre-adipocyte proliferative and differentiation effects of BPA and explored putative signal factors which partly explain adipose responses and underlying epigenetic mechanisms mediated by BPA. Maternal BPA-induced offspring adiposity, hypertrophic adipocytes and increased adipose tissue protein expression of pro-adipogenic and lipogenic factors. Consistent with in vivo data, in vitro BPA exposure induced a dose-dependent increase in pre-adipocyte proliferation and increased adipocyte lipid content. In vivo and in vitro BPA exposure promotes the proliferation and differentiation of adipocytes, contributing to an enhanced capacity for lipid storage. These findings re...Continue Reading

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Citations

Nov 2, 2019·Journal of Food Science·Giacomo RussoLucia Grumetto
Jan 10, 2020·Environmental Science and Pollution Research International·Rania Abdelrahman ElgawishHeba M A Abdelrazek
Feb 23, 2019·Frontiers in Endocrinology·Beverly S RubinAna M Soto
Sep 14, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Chalana M SolVincent W V Jaddoe
Jan 19, 2020·Environmental Science and Pollution Research International·Xia WangFengxiu Ouyang
Feb 26, 2020·Nutrients·Tiziana FilardiSusanna Morano
Mar 25, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Amanda Rodgers, Amanda N Sferruzzi-Perri
Nov 9, 2020·Environmental Toxicology and Pharmacology·Ayse Basak Engin, Atilla Engin
May 11, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Ronald BiemannBerend Isermann
Jun 3, 2021·International Journal of Molecular Sciences·Isabel C CohenSonya M Schuh
Jun 3, 2021·Nutrients·Virginia Robles-AguileraAna Rivas

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