PMID: 2507310Oct 1, 1989Paper

In vivo and in vitro dermal penetration of 2,4,5,2',4',5'-hexachlorobiphenyl in young and adult rats

Environmental Research
H L FisherL L Hall

Abstract

Penetration of 2,4,5,2',4',5'-[14C]hexachlorobiphenyl (HCB) through skin of young (33 days) and adult (82 days) female Fischer 344 rats was determined in vivo and by two in vitro methods. In vivo dermal penetration at 120 hr was 45% in young and 43% in adults. At 72 hr in vivo dermal penetration was 35% in young and 26% in adults compared to 1.5% for young and 1.0% for adult as measured with a continuous flow in vitro system and 2.9% for young and 1.9% for adults as measured with a static in vitro system. Most of the dermally absorbed HCB remained in the body as only 4.9 and 2.6% of that absorbed was excreted by young and adult rats, respectively, at the end of 120 hr. Significant differences in dermal penetration and kinetics of HCB between young and adult female rats were observed. The elimination of HCB-derived material was approximately six times higher in feces than in urine. A physiological pharmacokinetic model was fitted to the organ and tissue radioactivity distribution data. Parameters in the model determined from dermal dosing of female Fischer 344 rats were in reasonable agreement with those reported in the literature for adult male Sprague-Dawley rats (iv dose). The rat constant for dermal penetration was 0.83 x 10...Continue Reading

References

May 1, 1979·Toxicology and Applied Pharmacology·N M MoralesH B Matthews
Jul 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H B MatthewsF E Guthrie
Jan 1, 1987·Journal of Toxicology and Environmental Health·P V ShahL L Hall
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Jan 1, 1985·Journal of Pharmaceutical Sciences·R L Bronaugh, R F Stewart
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Apr 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S Mühlebach, M H Bickel

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Citations

May 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M F HughesL L Hall
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M F HughesB Bhooshan
Jul 1, 1992·Journal of Toxicology and Environmental Health·H L FisherP V Shah
Apr 18, 2001·Biological & Pharmaceutical Bulletin·T NgawhirunpatI Adachi
Sep 17, 2002·Biological & Pharmaceutical Bulletin·Tanasait NgawhirunpatIsao Adachi
Dec 1, 1995·Environmental Health Perspectives·R P Moody, I Chu
Feb 12, 1998·Environmental Health Perspectives·J G SarverK Bachmann
Dec 15, 2007·Reviews on Environmental Health·Lamar ReedPaul B Tchounwou
May 8, 1998·Toxicology and Applied Pharmacology·C E Garner, H B Matthews
Dec 8, 1998·Environmental Research·A C HeatheringtonL L Hall

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