PMID: 7521961Oct 1, 1994Paper

In vivo and in vitro effects of androgen on fibroblast growth factor-2 concentrations in the human prostate

The Prostate
J GellerR M Hoffman

Abstract

Prostatic growth is primarily regulated by dihydrotestosterone (DHT). Recent studies have demonstrated that a large number of growth factors are present in the human benign prostatic hyperplasia (BPH) prostate, including epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), transforming growth factor beta (TGF-beta), insulin-like growth factor (IGF), and basic fibroblast growth factor (bFGF) (FGF-2). DHT may mediate its mitogenic effects in the prostate by regulating growth factors. To test this hypothesis, we have utilized a histoculture androgen sensitivity assay (HASA) in which 3H-thymidine incorporation is measured in aliquots of BPH tissue in histoculture with either added DHT or hydroxyflutamide (HF). The resulting DHT/HF ratio is an expression of the androgen sensitivity of the tissue. In this study, we have compared the DHT/HF ratio for 3H-thymidine incorporation to the DHT/HF ratio for FGF-2 measured in the histocultured prostates. The DHT/HF ratio for the HASA studies of 3H-thymidine incorporation averaged 2.68 compared to the DHT/HF ratio for FGF-2 in the same specimens of 1.01. These values were significantly different, therefore indicating no relationship between DHT stimulation and FGF-2 lev...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A TanakaK Matsumoto
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·B ZuckC Knabbe
Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·P CohenR G Rosenfeld

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