PMID: 6539286May 1, 1984Paper

In vivo and in vitro effects of caffeine on hepatic mixed-function oxidases in rodents and chicks

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
S P GovindwarS S Pawar

Abstract

Administration of caffeine, ip 100 mg/kg/day for 1-5 days, to adult male rats resulted in a significant increase in hepatic cytochrome P-450 and b5 concentrations and in cytochrome c reductase, aminopyrine N-demethylase and acetanilide hydroxylase activities. No change was seen in relative liver weight but microsomal protein content was increased after treatment for 1 day and decreased after treatment for 3 or 5 days. In adult rats given 25, 100 or 150 mg caffeine/kg for 3 days, maximum stimulation of mixed-function oxidases was seen with the 100-mg/kg dose. Caffeine treatment (100 mg/kg for 3 days) increased relative liver weight in female guinea-pigs and decreased it in chicks and female mice, and decreased microsomal protein content in male mice, female guinea-pigs and young rats, and increased it in chicks. A significant increase in hepatic cytochrome P-450 content was seen in all species studied. Cytochrome b5 content was increased in chicks and young rats, while cytochrome c reductase activity was increased in male and female mice, young rats and chicks and decreased in female guinea-pigs. Aminopyrine N-demethylase activity was increased in young rats and female guinea-pigs, and acetanilide hydroxylase was increased in al...Continue Reading

References

Jul 1, 1978·Clinical Pharmacology and Therapeutics·W D Parsons, A H Neims
Jan 1, 1975·Drug Metabolism Reviews·A W Burg
Sep 1, 1975·Toxicology and Applied Pharmacology·H U Aeschbacher, H P Würzner
May 1, 1973·Chemico-biological Interactions·R C BakerE Hodgson
Jul 1, 1970·Biochemical Pharmacology·L Lombrozo, C Mitoma
Feb 1, 1973·Food and Cosmetics Toxicology·K L Khanna, H H Cornish
Nov 1, 1969·Archives of Biochemistry and Biophysics·C MitomaF Dehn
Feb 1, 1968·Life Sciences·C MitomaS E Neubauer

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Citations

Jan 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A NishikawaM Takahashi

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