PMID: 6967680Jan 1, 1980Paper

In vivo and in vitro effects of lithium on granulopoiesis in human neutropenic disorders

Advances in Experimental Medicine and Biology
W A RobinsonR Gupta

Abstract

Studies have been cazrried out to determine the in vivo and in vitro effects of lithium carbonate in various neutropenic disorders. Addition of lithium to culture of bone marrow from patients with a variety of neutropenic disorders and ANLL in which normal or elevated serum and/or urinary CSA levels were present did not enhance granulocyte colony formation. Administration of lithium carbonate to patients with Felty's syndrome, in which serum and urinary CSA levels are reduced, enhanced peripheral blood neutrophil levels and serum and urinary CSA values. Lithium administration appears to be most beneficial in neutropenic patients in whom it can be demonstrated that CSA production is reduced.

Citations

Jun 16, 2009·Cell Transplantation·Wise Young
Nov 30, 2011·Current Opinion in Hematology·Mario Petrini, Antonio Azzarà

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