In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: correlation with somatostatin and dopamine D2 receptor scintigraphy

Clinical Endocrinology
Diego FeroneAnnamaria Colao

Abstract

GH and PRL cosecretion frequently occurs in acromegaly and the sensitivity of both hormones to somatostatin analogs (SA) and dopamine agonists (DA) alone or in combination, is still debated. This study was designed to evaluate the in vivo and in vitro sensitivity to SA and/or DA and correlate the response in terms of hormone suppression to the results of in vivo somatostatin and dopamine receptor scintigraphy and to the immunohistochemical findings. Scintigraphy using 111In-DTPA-D-Phe(1)-OCT (111In-OCT) and 123I-methoxybenzamide (123I-IBZM) was performed in four patients with acromegaly and high circulating GH, PRL and IGF-I levels. The results were correlated with the response to long-term treatment with octreotide (OCT), quinagolide (QN) and/or cabergoline (CAB), to the in vitro hormone suppression by OCT and DA in primary cultures from the pituitary tumors and to the immunohistochemical findings. The first patient showed high tumour uptake of 111In-OCT and 123I-IBZM, the second high uptake of only 111In-OCT, while the third one showed faint tumour uptake of only 123I-IBZM, and the fourth a faint uptake of 111In-OCT. In the first and in the fourth patients OCT or CAB administered alone failed to normalize hormone levels while...Continue Reading

References

May 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J HalseJ Jervell
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M BassettiG Giannattasio
Apr 1, 1995·Baillière's Clinical Endocrinology and Metabolism·K ThaparP J Muller
May 1, 1995·European Journal of Endocrinology·G LombardiB Merola
Jan 25, 1996·The New England Journal of Medicine·S W LambertsL J Hofland
Jun 1, 1996·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Dec 1, 1996·Clinical Endocrinology·W W de HerderS W Lamberts
Feb 19, 1998·The Journal of Clinical Endocrinology and Metabolism·R AbsA Beckers
Dec 16, 1998·European Journal of Endocrinology·R CozziD Gelli

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Citations

Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G VitaleA Colao
Oct 22, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J W Evans, A M Peters
Feb 19, 2004·Cancer Biotherapy & Radiopharmaceuticals·Lisa BodeiDik J Kwekkeboom
Apr 7, 2007·European Journal of Endocrinology·Diego FeronePhilippe Jaquet
Apr 7, 2007·European Journal of Endocrinology·Diego FeroneFrancesco Minuto
Apr 7, 2007·European Journal of Endocrinology·Wouter W de HerderDik J Kwekkeboom
Apr 7, 2007·European Journal of Endocrinology·Annamaria ColaoGaetano Lombardi
Feb 16, 2005·Reviews in Endocrine & Metabolic Disorders·Wouter W de Herder, Steven W J Lamberts
Mar 1, 2006·Expert Opinion on Investigational Drugs·Angela N Paisley, Peter J Trainer
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Gemma SesmiloAnne Klibanski
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Diego FeroneAntonina Barreca

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