In vivo and in vitro efficacies of mebendazole, mefloquine and nitazoxanide against cyst echinococcosis

Parasitology Research
Congshan LiuWei Hu

Abstract

Echinococcus granulosus is a cestode parasite. The metacestode stage causes cystic echinococcosis (CE) mainly in the human liver and lung. Current chemotherapy against CE is based on mebendazole and albendazole. However, benzimidazoles result in a low cure rate or are ineffective in many patients; therefore, novel compounds for the treatment of this disease have been studied. Mefloquine was reported to be dramatically effective on cultured Echinococcus multilocularis metacestodes in vitro. And, nitazoxanide has a prominent protoscolicidal effect. However, these compounds have no impact on the growth of cysts harbored in mice. In this study, we investigated the in vitro and in vivo efficacy of mebendazole, mefloquine, and nitazoxanide against E. granulosus protoscoleces, germinal cells, and infected mice. The effect of mebendazole on protoscoleces and germinal cell was proved to be dose-dependent in vitro. And, a reduction of the cyst weight was also the found after oral application of mebendazole to infected mice. Mefloquine (5 and 10 μg/ml) caused death within 24 h of protoscoleces and germinal cells in vitro, whereas a lower concentration of 1 μg/ml was ineffective. In mice infected with E. granulosus, oral mefloquine (200 an...Continue Reading

References

Apr 1, 1988·International Journal for Parasitology·P L FioriP Cappuccinelli
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·G J FrayhaT A Kachachi
Feb 3, 2000·Annals of Tropical Medicine and Parasitology·K VutovaT Todorov
Oct 25, 2003·Lancet·Donald P McManusPaul B Bartley
Mar 17, 2004·International Journal of Pharmaceutics·K Daniel-MwambeteJ J Torrado
Jul 30, 2004·The Journal of Antimicrobial Chemotherapy·Mirjam WalkerAndrew Hemphill
Sep 7, 2006·Antimicrobial Agents and Chemotherapy·Arunasalam NaguleswaranAndrew Hemphill
Dec 16, 2006·Parasitology Research·M ElissondoG Denegri
Feb 1, 2008·Parasitology International·M Celina ElissondoGuillermo Denegri
Jun 3, 2008·Veterinary Parasitology·Adriano CasulliEdoardo Pozio
Sep 2, 2008·Travel Medicine and Infectious Disease·Luc Van NassauwJozef Vercruysse
Oct 22, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Pedro Moro, Peter M Schantz
Mar 20, 2009·Journal of Helminthology·A Hemphill, J Müller
Jan 30, 2010·Parasitology Research·Mohammad Moazeni, Sara Larki
Dec 8, 2010·Antimicrobial Agents and Chemotherapy·Tatiana KüsterAndrew Hemphill
Feb 5, 2011·The American Journal of Tropical Medicine and Hygiene·José A Pérez-MolinaRogelio López-Vélez
Jul 20, 2011·Antimicrobial Agents and Chemotherapy·Britta StadelmannAndrew Hemphill
Aug 17, 2011·Parasitology Research·Marina A MaggioreMaría Celina Elissondo
Jan 17, 2012·Veterinary Parasitology·Mohammad MoazeniAli Akbar Hosseini
May 28, 2013·The Korean Journal of Parasitology·Hailong LvYufeng Jiang
Jul 19, 2013·Acta Tropica·Clara María AlbaniGuillermo María Denegri
Aug 28, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Soheila RouhaniFarid Zayeri
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar

❮ Previous
Next ❯

Citations

Nov 14, 2019·The Korean Journal of Parasitology·Wen WangJiaqing Zhao
Feb 15, 2019·Clinical Microbiology Reviews·Hao WenDonald P McManus
Sep 9, 2020·Scientific Reports·K A YamamotoM R Soares
Apr 9, 2020·Frontiers in Cellular and Infection Microbiology·Congshan LiuHaobing Zhang
Oct 22, 2020·Acta Biochimica Et Biophysica Sinica·Rongji MaHailong Lv
Jul 4, 2021·Acta Tropica·Nayana Ferreira de LimaMarina Clare Vinaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.