In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Ketan MarballiConsuelo Walss-Bass

Abstract

Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune system response. We therefore hypothesized that a schizophrenia-associated missense mutation (valine to leucine) we identified within the transmembrane region of NRG1 would also be linked to immune dysregulation. We used plasma samples from families carrying the mutation to measure levels of antibodies to 41 autoimmune markers and six cytokines (IL-1b, IL-6, IL-10, IL-8, IL-12p70, and TNF-α) and used these levels as quantitative traits to evaluate association with the NRG1 mutation, using FBAT. Next, we used Epstein-Barr virus-transformed B cells from heterozygous mutation carriers and wild-type individuals to evaluate protein and mRNA cytokine expression in vitro using quantitative PCR and ELISA assays. In vivo, increased levels of 25 autoimmune markers as well as elevated levels of cytokines were significantly associated with the NRG1 mutation. In vitro, we observed a significant increase in protein secretion levels of IL-6, TNF-α, and IL-8 in mutation carriers compared with controls. At the mRNA level, we ...Continue Reading

References

Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
Jul 27, 2002·Cellular Immunology·Yongmao YuMichael Schlesinger
Nov 28, 2002·American Journal of Human Genetics·Christoph LangeNan M Laird
Mar 7, 2003·Journal of Neuroimmunology·Filomena O DimayugaAnnadora J Bruce-Keller
Mar 22, 2003·Experimental Cell Research·Douglas L Falls
Jun 25, 2003·The Journal of Cell Biology·Jianxin BaoDavid A Talmage
Mar 30, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Edward MorganAmitabh Gaur
Jan 6, 2006·Current Directions in Autoimmunity·Paula B Deming, Jeffrey C Rathmell
Mar 4, 2006·The American Journal of Psychiatry·William W EatonPreben Bo Mortensen
May 30, 2006·Biological Psychiatry·Consuelo Walss-BassHenriette Raventos
Sep 26, 2006·Journal of Autoimmunity·Rael D Strous, Yehuda Shoenfeld
Oct 3, 2006·Journal of the American College of Cardiology·Neil J Freedman, Geoffrey S Ginsburg
Apr 24, 2007·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Mirka HintsanenLiisa Keltikangas-Järvinen
Jul 21, 2007·The Journal of Clinical Investigation·Tianfu WuChandra Mohan
Sep 29, 2007·European Archives of Psychiatry and Clinical Neuroscience·Kari HänninenTerho Lehtimäki
Nov 6, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Colm M P O'TuathaighJohn L Waddington
Nov 17, 2007·Biological Psychiatry·Stéphane PotvinEdouard Kouassi
Nov 27, 2007·Neuropsychobiology·Kyeong-Sae Na, Yong-Ku Kim
Apr 17, 2008·Journal of Mammary Gland Biology and Neoplasia·Nandini V L Hayes, William J Gullick
May 10, 2008·Biological Psychiatry·Lyudmila GeorgievaMichael C O'Donovan
May 15, 2008·Nature Reviews. Neuroscience·Lin Mei, Wen-Cheng Xiong
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·T DejaegereB De Strooper
Nov 27, 2008·American Heart Journal·Vicente BodiAngel Llacer
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jose F CamargoSunil K Ahuja
Mar 11, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·April KalinowskiKerry S Russell

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Citations

Apr 30, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Joana M XavierSofia A Oliveira
Oct 5, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert E McCullumsmithJames H Meador-Woodruff
Nov 16, 2013·Current Heart Failure Reports·Cristi L GalindoDouglas B Sawyer
Jun 5, 2014·Brain : a Journal of Neurology·Oscar G VidaurrePatrizia Casaccia
Apr 19, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brian J MillerPeter Buckley
Jul 25, 2012·Annals of the New York Academy of Sciences·Michael E BenrosWilliam W Eaton
Apr 16, 2014·International Reviews of Immunology·Kolandaswamy AnbazhaganFlorence Apparailly
Nov 6, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kyoung-Sae NaYong-Ku Kim
Nov 19, 2011·Multiple Sclerosis International·Evgenia Tynyakov-SamraArnon Karni
Jul 2, 2016·Biological Psychiatry·Michael E BenrosEsben Agerbo
Jun 11, 2016·Neuroscience and Biobehavioral Reviews·Md Shaki MostaidChad A Bousman
Apr 29, 2015·PloS One·Michelle DayaEileen G Hoal
Nov 11, 2016·Oxidative Medicine and Cellular Longevity·Bożena Adamczyk, Monika Adamczyk-Sowa
Apr 25, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin J Schmidt, Karoly Mirnics
Jul 14, 2017·Expert Review of Respiratory Medicine·Craig KinnearMarlo Möller
Jan 13, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Haldun Arpacı
Feb 27, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Sergey RyzhovDouglas B Sawyer
Oct 12, 2016·Neural Plasticity·Paula MoranColm O'Tuathaigh
Oct 5, 2019·Oxidative Medicine and Cellular Longevity·Carmen Navarro-GonzálezPietro Fazzari
Dec 15, 2020·Brain : a Journal of Neurology·Hardeep KatariaSoheila Karimi-Abdolrezaee

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