PMID: 9162527Apr 1, 1996Paper

In vivo and In vitro interferon induction in chickens by S -28828, an imidazoquinolinamine immunoenhancer

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
K KaracaR L Miller

Abstract

Imiquimod and its analogs belonging to a class of imidazoquinolinamines, activate immune system via cytokine induction, and have antitumor and antiviral effects in mammals. In this study, we showed that a related analog, designated S-28828, induced interferon (IFN) and macrophage activating cytokine(s) (macrophage activating factor, MAF) in chickens in vivo, ex vivo, and in vitro. IFN and MAF were detectable in the serum of chickens following oral administration. Serum IFN levels were the highest at 2 h after treatment. Although there was no detectable IFN in sera of chickens at 8, 24, and 48 h after treatment, high levels of interferon inducible enzyme, 2'-5' oligoadenylate synthase (2'5'OAS) were present at these time points. In vitro and ex vivo studies showed that spleen cells, bone marrow (BM) cells, and peripheral blood leukocytes (PBL) were capable of producing IFN and MAF, although spleen cells produced the highest levels. Our results suggest that S-28828 administered orally may be a useful immunoenhancing and antiviral agent for chickens.

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Citations

Mar 16, 2000·Developmental and Comparative Immunology·S Rautenschlein, J M Sharma
May 17, 2008·Avian Pathology : Journal of the W.V.P.A·S K ReddyJ A Newman
Mar 10, 2004·The Journal of Experimental Medicine·Cory L AhonenRoss M Kedl
Apr 16, 2004·Clinical Microbiology Reviews·Andrew J EastonHelene F Rosenberg
Dec 23, 2008·Developmental and Comparative Immunology·Kristie A JenkinsAndrew G D Bean
Sep 15, 2015·Avian Pathology : Journal of the W.V.P.A·Sandra HartmannSilke Rautenschlein
Jan 9, 2007·Veterinary Immunology and Immunopathology·Martin Liman, Silke Rautenschlein
Mar 23, 2013·Journal de mycologie médicale·M SoltaniH Shokri
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christie L DoxseeRoss M Kedl
Aug 8, 2001·European Journal of Biochemistry·K SchneiderP Staeheli

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