PMID: 8594878Dec 1, 1995Paper

In vivo and in vitro pressor effects of erythropoietin in rats

The American Journal of Physiology
N D VaziriR E Purdy

Abstract

Hypertension (HTN) is a common complication of recombinant erythropoietin (EPO) therapy, but the mechanism of the EPO-associated HTN is uncertain. In the present study we examined the effects of EPO and the vehicle alone on rat caudal artery contractile response and basal and thrombin-stimulated platelet cytosolic Ca2+ concentration ([Ca2+]i) in vitro and on blood pressure (BP) and heart rate in vivo. At high concentrations (200 U/ml) EPO caused a small but consistent contraction in the caudal artery rings (P < 0.01) without affecting the response to either angiotensin II (ANG II) or the alpha 1-agonist methoxamine. Incubation with EPO significantly increased basal platelet [Ca2+]i (P < 0.01) and augmented the thrombin-induced rise of [Ca2+]i in Ca(2+)-free medium (P < 0.05). Long-term EPO administration led to a significant elevation of BP within 2 wk regardless of whether the hematocrit was allowed to rise or was kept constant by dietary iron deficiency. In contrast, single intravenous administration of high-dose EPO (400 and 5,000 U/kg), estimated to yield plasma concentrations comparable with those employed in vitro, failed to either alter BP or modify the BP response to ANG II during a 60-min observation period. This was a...Continue Reading

Citations

Nov 7, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nosratola D Vaziri, Xin J Zhou
Feb 27, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Han BaoYing-Xin Qi
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·B R WalkerL D Nelin
Mar 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Young-Ki LeeNosratola D Vaziri

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