In vivo and in vitro regulation of hepatic glucagon receptor mRNA concentration by glucose metabolism.

The Journal of Biological Chemistry
R BurcelinM J Charron

Abstract

We have recently cloned the murine glucagon receptor (GR) gene and shown that it is expressed mainly in liver. In this organ, the glucagon-GR system is involved in the control of glucose metabolism as it initiates a cascade of events leading to release of glucose into the blood stream, which is a main feature in several physiological and pathological conditions. To better define the metabolic regulators of GR expression in liver we analyzed GR mRNA concentration in physiological conditions associating various glucose metabolic pathways in vivo and in vitro in the rat and in the mouse. First, we report that the concentration of the GR mRNA progressively increased from the first day of life to the adult stage. This effect was abolished when newborn rodents were fasted. Second, under conditions where intrahepatic glucose metabolism was active such as during fasting, diabetes, and hyperglycemic clamp, the concentration of GR mRNA increased independent of the origin of the pathway that generated the glucose flux. These effects were blunted when hyperglycemia was corrected by phlorizin treatment of diabetic rats or not sustained during euglycemic clamp. In accordance with these observations, we demonstrated that the glycolytic substr...Continue Reading

References

Mar 15, 1977·The Biochemical Journal·D F HeathJ G Rose
Jan 1, 1992·Annual Review of Physiology·S J Pilkis, D K Granner
May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·A D CherringtonO P McGuinness
Sep 1, 1991·European Journal of Biochemistry·A Vandercammen, E Van Schaftingen
Jan 1, 1991·Metabolism: Clinical and Experimental·S R MyersA D Cherrington
Mar 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E Van Schaftingen, D R Davies
Sep 11, 1990·European Journal of Biochemistry·D R DaviesE Van Schaftingen
Jan 1, 1990·Biology of the Neonate·J Girard
Jul 31, 1990·European Journal of Biochemistry·A Vandercammen, E Van Schaftingen
Jan 15, 1989·European Journal of Biochemistry·E Van Schaftingen, A Vandercammen
Dec 1, 1988·International Journal of Peptide and Protein Research·H KofodR B Merrifield
Jan 1, 1986·Biology of the Neonate·J F DecauxJ Girard
May 1, 1987·The Journal of Clinical Investigation·L RossettiR A DeFronzo
Dec 1, 1973·The Journal of Clinical Investigation·J R GirardR Assan
Jun 30, 1995·The Journal of Biological Chemistry·N AbrahamsenE Nishimura
Oct 6, 1995·The Journal of Biological Chemistry·H C Towle
Jul 1, 1995·The Journal of Clinical Investigation·P BoileauS Hauguel-de Mouzon
Mar 23, 1994·Biochimica Et Biophysica Acta·M J YounusP J Butterworth
Jul 1, 1993·The British Journal of Nutrition·A J LepineD M Whitehead
Apr 26, 1996·The Journal of Biological Chemistry·D MassillonL Rossetti
Mar 1, 1996·Obstetrics and Gynecology Clinics of North America·G Boden

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Citations

Dec 30, 2004·Diabetes/metabolism Research and Reviews·Joel R L EhrenkranzJesse Roth
Sep 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Carole Lavoie
Jan 5, 2014·Canadian Journal of Physiology and Pharmacology·Jamilur R TalukderJaleesa Wright
Jun 14, 2005·Expert Opinion on Therapeutic Targets·Kyle W SloopJulie S Moyers
Jun 5, 2012·Pharmacology & Therapeutics·Young Min ChoTimothy J Kieffer
Jan 20, 2011·Journal of Pineal Research·Ina BährElmar Peschke
Dec 27, 2011·Biochemical and Biophysical Research Communications·Katsumi IizukaYukio Horikawa
Oct 21, 1999·Molecular Genetics and Metabolism·M SvobodaW J Malaisse
Jan 29, 2002·Diabetes·Fatima SmihDominique Langin
Jun 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sergio PolakofJosé L Soengas
Feb 3, 2005·American Journal of Physiology. Endocrinology and Metabolism·Alexandre CharbonneauJean-Marc Lavoie
Apr 17, 2003·Endocrinology·Naira GorovitsMaureen J Charron
Mar 13, 1999·The Journal of Biological Chemistry·L PortoisM Svoboda
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·A LégaréC Lavoie
Feb 24, 2001·Annals of the New York Academy of Sciences·L PortoisM Svoboda
Jun 16, 2019·Archives of Gynecology and Obstetrics·Engy ShokryBerthold Koletzko

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