PMID: 337921Oct 24, 1977

In vivo and in vitro studies on the glucose dependent inactivation of yeast cytoplasmic malate dehydrogenase

Archives of Microbiology
J Neeff, D Mecke


The cytoplasmic malate dehydrogenase in the yeast Saccharomyces cerevisiae is known to be inactivated by a glucose dependent process. In this paper it is shown that in vivo effectors of the glucose metabolism (arsenate, iodoacetate, acetaldhyde) inhibit the inactivation or change the inactivation kinetics. In vitro it was possible to inactivate the malate dehydrogenase by addition of the glucose metabolite glyceraldehyde 3-phosphate. The physiological relevance of this modification and the effect of malate dehydrogenase inactivation on the glyoxylate cycle in yeast is discussed.


May 1, 1971·Journal of Bacteriology·H P Klein, L Jahnke
Jan 1, 1970·Archives of Biochemistry and Biophysics·P S Perlman, H R Mahler
Apr 1, 1966·The Biochemical Journal·H L Kornberg
Feb 5, 1971·Biochemical and Biophysical Research Communications·F J Yost, J H Harrison
Jun 11, 1971·European Journal of Biochemistry·L KopelovichJ S. Nisselbaum
Jan 1, 1968·European Journal of Biochemistry·W DuntzeH HOLZER
Mar 1, 1967·European Journal of Biochemistry·J J FergusonH HOLZER
Apr 1, 1958·Journal of Bacteriology·M E GREIGA J GIBBONS
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·H HOLZER


Feb 2, 1982·Biochimica Et Biophysica Acta·M DuszenkoD Mecke
Aug 30, 2001·Applied and Environmental Microbiology·C CamarasaS Dequin
Sep 1, 2005·Yeast·James A Barnett, Karl-Dieter Entian
Sep 2, 2008·FEMS Microbiology Reviews·Margarida CasalIsabel Soares-Silva

Related Concepts

Cell-Free System
Enzyme Repression
Anhydrous Dextrose
Calcium Glycerophosphate
Iodoacetic Acids
Malate Dehydrogenase
Saccharomyces cerevisiae

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