In vivo animal studies help achieve international consensus on standards and guidelines for health risk estimates for chronic exposure to low levels of tritium in drinking water

Environmental and Molecular Mutagenesis
Yann GuéguenDmitry Klokov

Abstract

Existing and future nuclear fusion technologies involve the production and use of large quantities of tritium, a highly volatile, but low toxicity beta-emitting isotope of hydrogen. Tritium has received international attention because of public and scientific concerns over its release to the environment and the potential health impact of its internalization. This article provides a brief summary of the current state of knowledge of both the biological and regulatory aspects of tritium exposure; it also explores the gaps in this knowledge and provides recommendations on the best ways forward for improving our understanding of the health effects of low-level exposure to it. Linking health effects specifically to tritium exposure is challenging in epidemiological studies due to high uncertainty in tritium dosimetry and often suboptimal cohort sizes. We therefore argued that limits for tritium in drinking water should be based on evidence derived from controlled in vivo animal tritium toxicity studies that use realistically low levels of tritium. This article presents one such mouse study, undertaken within an international collaboration, and discusses the implications of its main findings, such as the similarity of the biokinetics...Continue Reading

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Citations

Dec 26, 2018·International Journal of Radiation Biology·Yi WangDmitry Klokov
Dec 21, 2019·Environmental Toxicology and Chemistry·Béatrice GagnaireChristelle Adam-Guillermin
Jun 17, 2021·International Journal of Radiation Biology·Vinita ChauhanDebora Quayle
Jul 25, 2021·International Journal of Molecular Sciences·Abrar Ul Haq KhanYevgeniya Le

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