In vivo antagonism of the behavioral responses to L-3-,4-dihydroxyphenylalanine by L-3-,4-dihydroxyphenylalanine cyclohexyl ester in conscious rats

European Journal of Pharmacology
Naoko MatsushitaY Goshima


To establish the neurotransmitter role(s) of L-3,4-dihydroxyphenylalanine (DOPA) in its own right, we attempted to clarify whether i.p. injection of a DOPA antagonist, DOPA cyclohexyl ester (CHE), would antagonize the behavioral responses of conscious rats to DOPA in the presence of 3-hydroxybenzylhydrazine (NSD-1015) (100 mg/kg i.p.), a central aromatic L-amino acid decarboxylase (AADC) inhibitor. DOPA-CHE (40, 60 and 100 mg/kg) elicited a dose-dependent partial antagonism against the increase in locomotor activity induced by DOPA (100 mg/kg i.p.). A low dose of DOPA-CHE (10 mg/kg) elicited full antagonism against the potentiating effect of a non-effective dose of DOPA (20 mg/kg) on the increase in locomotor activity induced by a dopamine D(2) agonist quinpirole (0.3 mg/kg s.c.). DOPA-CHE (100 mg/kg) elicited full antagonism against licking behavior induced by DOPA (100 mg/kg). We confirmed that DOPA (100 mg/kg) increased the striatal dopamine content but elicited no effect on locomotor activity in the presence of benserazide (50 mg/kg i.p.), a peripheral AADC inhibitor. DOPA also increased the dopamine content in the presence of NSD-1015 to a maximal degree similar to that in the presence of benserazide. Thus, we conclude tha...Continue Reading


Aug 1, 1987·The Journal of Pharmacy and Pharmacology·D R CooperC D Marsden
Aug 1, 1996·Progress in Neurobiology·Y MisuH Okamura
Jun 27, 2002·Trends in Pharmacological Sciences·Yoshimi MisuTakeaki Miyamae
Feb 1, 2003·Pharmacology & Therapeutics·Yoshimi MisuYoshio Goshima
Mar 27, 2003·Journal of Neural Transmission·S A TresederP Jenner

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Apr 9, 2013·Neuroscience Letters·Scott AytonDavid I Finkelstein
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