PMID: 6976330Aug 15, 1981Paper

In vivo anti-tumor effects of local adoptive transfer of mouse and human cultured lymphoid cells

International Journal of Cancer. Journal International Du Cancer
E GorelikR B Herberman

Abstract

Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells and had characteristics of natural killer cells. These cultured cells were evaluated for their in vivo cytotoxic activity by a mixture with [125I]dUrd-labelled M109 tumor cells (2 x 10(5)) at a 30:1 ratio and inoculation of the mixture into the footpads of BALB/c mice. The level of radioactivity remaining in the footpad was determined at various periods following inoculation of radiolabelled tumor cells. The presence of cultured cells in the inocula caused a marked decrease in the footpad radioactivity by 24 h. However, the slope of clearance of the radiolabel then became similar to that in the control mice. The cultured cells delayed, but did not prevent, tumor appearance, and did not influence the subsequent rate of growth of the tumors. The transient effects of the cultured cells contrasted with the more prolonged in vivo effects of alloimmune lymphocytes, and this may be due to their short survival period. Nine...Continue Reading

References

Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Jul 14, 1977·Nature·S Gillis, K A Smith
Jan 1, 1977·Advances in Cancer Research·S A Rosenberg, W D Terry
Nov 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·R H BassinE W Chu
May 15, 1981·International Journal of Cancer. Journal International Du Cancer·E Gorelik, R B Herberman

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