In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors

Japanese Journal of Cancer Research : Gann
Y TsutsumiT Mayumi

Abstract

We previously reported that the optimally PEGylated tumor necrosis factor-alpha (MPEG-TNF-alpha), in which 56% of the TNF-alpha-lysine amino groups were coupled with polyethylene glycol (PEG), had about 100-fold greater anti-tumor effect than native TNF-alpha. Here, we assessed the usefulness of MPEG-TNF-alpha as a systemic anti-tumor therapeutic drug, using B16-BL6 melanoma and colon-26 adenocarcinoma, which have been reported to be resistant to TNF-alpha in vivo, as compared with Meth-A fibrosarcoma. MPEG-TNF-alpha markedly inhibited the growth of both tumors without causing any TNF-alpha-mediated side-effects, whereas native TNF-alpha had no anti-tumor effects and caused adverse side-effects. In addition, MPEG-TNF-alpha drastically inhibited the metastatic colony formation of B16-BL6 melanoma. MPEG-TNF-alpha may, thus, be a potential systemic anti-tumor therapeutic agent.

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Citations

Feb 21, 2002·The International Journal of Biochemistry & Cell Biology·Rong-Gui HuWang-Yi Liu
May 17, 2011·Chemistry Central Journal·Yasuo YoshiokaYasuo Tsutsumi
Jul 6, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadanori Mayumi
Jul 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jian-Qing GaoShinsaku Nakagawa
Jul 16, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fu-Qiang HuHong Yuan
Mar 30, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Shigeki KushidaTadao Ohn
Jul 3, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Pooja DubeyShiv Shankar Shukla
Jun 20, 2001·Biological & Pharmaceutical Bulletin·Y P LiJ H Zhu

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