In vivo antifungal effect of Combretum and Terminalia species extracts on cutaneous wound healing in immunosuppressed rats

Pharmaceutical Biology
P MasokoJ N Eloff

Abstract

Acetone leaf extracts of Combretaceae species Combretum imberbe Wawra, Combretum nelsonii Duemmer, Combretum albopunctatum Suesseng, and Terminalia sericea Burch ex DC and a mixture of asiatic acid and arjunolic acid isolated from C. nelsonii were tested for antifungal activity against Candida albicans, Cryptococcus neoformans, Microsporum canis, and Sporothrix schenckii on wounds of immunocompromised Wistar rats. The therapeutic agents were selected based on low MIC values ranging 0.02-2.5 mg/mL and low toxicity (LC50) ranging 75.7-168.6 microg/mL. Seven circular, full-thickness wounds were made on the back skin of 24 Wistar rats, under general anesthetic and using an aseptic technique. Rats were infected with different fungal pathogens in groups of six. The treatments were administered topically using 20% concentrations of each extract in aqueous cream. Amphotericin B was used as positive control. Erythema, exudate, crust formation, swelling, and ulceration were used to determine the wound healing process. Throughout the experiment, body temperature, measured using a subcutaneous probe, and weight of the rats were found to be within normal ranges. Epithelial closure in all rats occurred by 17 days. There was no significant di...Continue Reading

References

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Citations

Oct 7, 2011·Clinical Microbiology Reviews·Mônica Bastos de Lima BarrosArmando Oliveira Schubach
Feb 9, 2016·Journal of Microbiological Methods·Liliana ScorzoniMaria José Soares Mendes-Giannini
Aug 19, 2015·BioMedicine·Wen-Hu LiuMei-Chin Mong
Dec 21, 2014·Medical Mycology·Arunaloke ChakrabartiShanshan Li
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nehal M Elsherbiny, Mohammed M H Al-Gayyar
Mar 23, 2017·Journal of Medical Microbiology·Tarek A A MoussaSybren de Hoog
Oct 11, 2017·Pharmacognosy Reviews·Sameh SolimanAyman M Noreddin
Apr 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuting WangShujuan Sun
Sep 11, 2021·Frontiers in Microbiology·Alexander LammersMichael Lalk

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