PMID: 9639686Jun 26, 1998Paper

In vivo antigenotoxic effects of dietary agents and beverages co-administered with urethane: assessment of the role of glutathione S-transferase activity

Mutation Research
S K AbrahamP C Kesavan

Abstract

Antigenotoxic effects and changes in glutathione S-transferase (GST) activity were assessed in mice after oral co-administration of urethane (URE) with aqueous extracts of dietary vegetables (carrot, spinach and cabbage), spices (cinnamon, pepper, cumin, clove and cardamom), tea and coffee. The results of the genotoxicity assay (micronucleus test) demonstrated dose-related antigenotoxic effects after URE was co-administered with aqueous extracts of vegetables, spices, tea and coffee. Inhibition of GST activity was observed 4 h after treatment with URE alone. Co-administration of URE with extracts of vegetables, coffee and spices resulted in dose-related attenuation of the inhibitory effect of URE on GST activity. However, tea had no effect on inhibition of GST activity by URE. Hence an association between antigenotoxicity and GST activity could not be established.

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Citations

Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K Abraham
Nov 28, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R El HamssA Muñoz Serrano
May 11, 2011·Journal of Medicinal Food·América Castañeda SortibránRosario Rodríguez-Arnaiz
Oct 23, 2001·Drug and Chemical Toxicology·K PremkumarA Ramesh
May 14, 2005·Fitoterapia·K SelvendiranD Sakthisekaran
Oct 7, 2010·Critical Reviews in Food Science and Nutrition·Joerg GruenwaldNicole Armbruester
Apr 21, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P LaohavechvanichA J Ketterman

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