PMID: 2493578Mar 1, 1989Paper

In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline

Mutation Research
S Ghaskadbi, V G Vaidya

Abstract

We have previously shown that the common antiamebic drug diiodohydroxyquinoline (DIHQ) exhibits mutagenic activity in the in vivo micronucleus test in Swiss albino mice. Results of experiments undertaken to study the influence of ascorbic acid (vitamin C) on the mutagenicity of DIHQ in this model system showed that ascorbic acid acts as an antimutagen against DIHQ. The effective antimutagenic doses of ascorbic acid themselves do not show any genotoxic effects in this in vivo system. It will be necessary, however, to elucidate the mechanism of action of ascorbic acid as well as its effects on the therapeutic properties of DIHQ before a practical use of ascorbic acid is contemplated for this purpose.

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Citations

Jan 1, 1992·Teratogenesis, Carcinogenesis, and Mutagenesis·S GhaskadbiV G Vaidya
Jan 1, 1994·Teratogenesis, Carcinogenesis, and Mutagenesis·P K Khan, S P Sinha
Jan 1, 1993·Mutation Research·P K Khan, S P Sinha
Nov 8, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M V RaoM I Rajvanshi
Dec 22, 1998·Mutation Research·K K Vijayalaxmi, R Venu
Feb 1, 1992·Journal of Toxicology and Environmental Health·G Rivas-OlmedoE Madrigal-Bujaidar
Jan 1, 1990·Food Additives and Contaminants·C K Chow
May 8, 2000·Journal of Applied Toxicology : JAT·M A Fahmy, F A Aly
Apr 8, 2020·Antimicrobial Agents and Chemotherapy·Nader S Abutaleb, Mohamed N Seleem
Oct 8, 2019·International Journal of Medical Microbiology : IJMM·Julio C CarreroMireya de la Garza
Mar 7, 2021·Research in Veterinary Science·Junqiang LiLongxian Zhang

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