In vivo aortic valve thermal heterogeneity in patients with nonrheumatic aortic valve stenosis the: first in vivo experience in humans

Journal of the American College of Cardiology
Konstantinos ToutouzasChristodoulos Stefanadis

Abstract

We investigated in vivo in aortic valve stenosis (AVS) whether there is: 1) thermal heterogeneity within the valve leaflets; 2) temperature difference between the leaflets and the ascending aortic wall; and 3) a possible correlation between heat production, inflammation, and neoangiogenesis. Histological studies have demonstrated a potential role of inflammation and neoangiogenesis in AVS. We examined 96 leaflets scheduled for aortic valve replacement. Twenty-five patients had AVS, and 7 had aortic valve insufficiency (AVI). Temperature measurements were performed right before hypothermic cardioplegia. Temperature difference (DeltaT) was assigned as the mean temperature of each leaflet minus the temperature of the aortic wall. Histological, immunohistological analysis, and vascular endothelial growth factor (VEGF) immunoreactivity was performed. Significant thermal heterogeneity was recorded within the leaflets of AVS, compared with AVI (1.52 +/- 1.35 degrees C vs. 0.13 +/- 0.11 degrees C, p < 0.01). In AVS DeltaT was greater in all leaflets compared with the AVI group (p < 0.01). Leaflets of AVS had increased inflammatory cell infiltration, calcium deposit, and anti-VEGF expression compared with AVI (p < 0.01). Thermal heterog...Continue Reading

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Citations

Apr 29, 2010·Current Cardiology Reports·Blase A Carabello
Dec 20, 2012·Current Cardiology Reports·Marc R DweckDavid E Newby
Apr 8, 2014·Virulence·Małgorzata Radwan-OczkoWojciech Kustrzycki
Jan 24, 2009·Journal of the American College of Cardiology·Anthony N DeMariaSotirios Tsimikas
Mar 1, 2012·Therapeutic Advances in Cardiovascular Disease·Alexandros AlexopoulosVlassios Pyrgakis
Mar 28, 2018·Journal of Cardiovascular Translational Research·Andreas SynetosDimitrios Tousoulis
Jul 9, 2013·Circulation Research·Blase A Carabello
Dec 7, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Shintaro HondaIsao Kubota
Apr 24, 2010·Current Opinion in Cardiology·Anthony S WierzbickiJohn B Chambers
Jul 31, 2013·Expert Review of Cardiovascular Therapy·George LazarosNalini Rajamannan

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