PMID: 1194351Nov 1, 1975Paper

In vivo assembly of tight junctions in fetal rat liver

The Journal of Cell Biology
R MontesanoL Orci

Abstract

Examination of glutaraldehyde-fixed, freeze-fractured livers from 14-15-day rat fetuses provided the basis for the following observations. Membrane particles align in otherwise poorly particulated areas of the presumptive pericanalicular plasma membrane (A face), frequently forming a discontinuous "honey-comb" network joining small particle islands. Even at this early stage, contiguous B-fracture faces contain furrows, rather than rows of pits, distinguishing the linear particle aggregates on the A face as developing tight junctions rather than gap junctions. Short segments of these linear arrays merge with smooth ridges clearly identifiable as segments of discontinuous tight junctions. With the continuing confluence of particulate and smooth ridge segments, mature tight junctions become fully appreciable. We conclude that tight junctions form de novo by the alignment and fusion of separate particles into beaded ridges which, in turn, become confluent and are transformed into continuous smooth ones. At 21 days of fetal life, most of the images of assembly have disappeared, and the liver reveals well-formed bile canaliculi sealed by mature tight junctions.

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Citations

Nov 1, 1975·The American Journal of Anatomy·R Montesano
Jul 1, 1979·The American Journal of Anatomy·I G Mobbs, D B McMillan
Jan 1, 1981·Cell and Tissue Research·C StolinskiB Martin
Aug 1, 1989·Cell and Tissue Research·L M Chapman, E M Eddy
Jan 1, 1980·Anatomy and Embryology·A J Zamora, D Thiesson
May 1, 1991·Cell and Tissue Research·F Suzuki, T Nagano
Jan 1, 1983·Anatomy and Embryology·J H YousonR R Shivers
Jan 1, 1981·Anatomy and Embryology·M MinuthR Taugner
Jan 1, 1981·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·M SpitznasE Reale
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J RassatH Themann
Nov 1, 1990·Cytotechnology·E FalcieriP Santi
Jan 1, 1985·The Journal of Membrane Biology·L Gonzalez-MariscalM Cereijido
Mar 31, 1980·The Journal of Membrane Biology·M CereijidoA M Palomo
Jan 1, 1984·The Journal of Membrane Biology·L González-MariscalM Cereijido
Apr 1, 1978·Developmental Biology·F Suzuki, T Nagano
Aug 1, 1981·Developmental Biology·J L MadaraJ S Trier
Sep 1, 1987·Developmental Biology·H FeracciA L Hubbard
Jan 1, 1977·Tissue & Cell·W J Larsen
Jan 1, 1980·Tissue & Cell·O Grynszpan-Wynograd, G Nicolas
Dec 1, 1979·Cell Differentiation·A Talmon, Y Ben-Shaul
Dec 1, 1976·Neuroscience·B Schnapp, E Mugnaini
Mar 1, 1977·Journal of Ultrastructure Research·R L Wood
Dec 12, 2002·Progress in Biophysics and Molecular Biology·L González-MariscalB E Jaramillo
Dec 1, 1985·The Journal of Cell Biology·J L Madara, K Dharmsathaphorn
Mar 1, 1976·The Journal of Cell Biology·R MontesanoL Orci

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