In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy

Cardiovascular Research
Anne-Marie L SeymourDamian J Tyler

Abstract

Left ventricular hypertrophy is an adaptive response of the heart to chronic mechanical overload and can lead to functional deterioration and heart failure. Changes in cardiac energy metabolism are considered as key to the hypertrophic remodelling process. The concurrence of obesity and hypertrophy has been associated with contractile dysfunction, and this work therefore aimed to investigate the in vivo structural, functional, and metabolic remodelling that occurs in the hypertrophied heart in the setting of a high-fat, high-sucrose, Western diet (WD). Following induction of cardiac hypertrophy through abdominal aortic banding, male Sprague Dawley rats were exposed to either a standard diet or a WD (containing 45% fat and 16% sucrose) for up to 14 weeks. Cardiac structural and functional characteristics were determined by CINE MRI, and in vivo metabolism was investigated using hyperpolarized (13)C-labelled pyruvate. Cardiac hypertrophy was observed at all time points, irrespective of dietary manipulation, with no evidence of cardiac dysfunction. Pyruvate dehydrogenase flux was unchanged in the hypertrophied animals at any time point, but increased incorporation of the (13)C label into lactate was observed by 9 weeks and maintai...Continue Reading

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Citations

Aug 25, 2015·Journal of Molecular and Cellular Cardiology·Jessica A M BastiaansenArnaud Comment
Jul 20, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jack J MillerDamian J Tyler
Jun 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Mark A PeterzanOliver J Rider
Oct 11, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Hikari A I YoshiharaJurg Schwitter
Jun 22, 2018·Frontiers in Cardiovascular Medicine·Qutuba G KarwiGary D Lopaschuk
Jun 20, 2019·Frontiers in Physiology·Alice P SowtonAndrew J Murray
May 24, 2018·Heart Failure Reviews·Liang ChenShengshou Hu
Jul 23, 2019·European Heart Journal Cardiovascular Imaging·Peter AggerChristoffer Laustsen
Mar 12, 2021·The Journal of Nutritional Biochemistry·Danielle Fernandes VileigasAntonio Carlos Cicogna
Aug 12, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rasmus Stilling TougaardHenrik Wiggers

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Methods Mentioned

BETA
ELISA
protein assay
electrophoresis

Software Mentioned

ImageJ
- IT
UN
jMRUI
SCAN

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