In vivo assessment of ergonovine-induced coronary artery spasm by 64-slice multislice computed tomography

Circulation. Cardiovascular Imaging
Tsuyoshi ItoTakahiko Suzuki

Abstract

The potential of multislice CT (MSCT) to predict coronary spasm has not been elucidated. The aim of this study was to investigate whether the morphological features observed on MSCT at the site of ergonovine-induced epicardial spasm could be used as diagnostic criteria for coronary spasm. A total of 296 plaques in 199 patients with clinically suspected coronary spastic angina without coronary stenosis (<75%) who underwent invasive angiography with intravenous ergonovine provocative testing were analyzed by MSCT. Calcification, CT attenuation, and patterns of vascular remodeling were evaluated in each plaque by MSCT. Plaques were divided into spasm group or nonspasm group based on the results of the ergonovine provocative test. On a per-plaque basis, noncalcified plaques were more frequently observed in the spasm group (96% versus 20%, P<0.01). Intermediate attenuation plaques (CT density ≥53.8 Hounsfield units identified by receiver operating characteristic analysis) were more common in the spasm group (93% versus 28%, P<0.01), as was negative remodeling (67% versus 11%, P<0.01). Multivariable analysis revealed noncalcified (odds ratio [OR], 48.7; 95% CI, 8.81-269; P<0.01), intermediate attenuation (OR, 19.3; 95% CI, 4.96-75.4;...Continue Reading

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Citations

Jun 19, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Peter OngUdo Sechtem
Jan 3, 2015·International Journal of Cardiology·Rex N MacAlpin
Dec 24, 2013·International Journal of Cardiology·Natale Daniele BrunettiMatteo Di Biase
May 4, 2016·The International Journal of Cardiovascular Imaging·Song Soo KimArthur E Stillman
Sep 20, 2012·Internal Medicine·Turgut KarabagEmrah Kucuk
Apr 18, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jiesuck ParkDae Won Sohn
Jun 10, 2020·Current Problems in Diagnostic Radiology·Joanna G EscalonDaniel Vargas

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