In vivo assessment of retinal vessel pathology in amyotrophic lateral sclerosis

Journal of Neurology
A AbdelhakElmar H Pinkhardt

Abstract

Changes in skin and muscle small blood vessels (SBVs) and microvascular structures of the brain have been reported in patients with amyotrophic lateral sclerosis (ALS). A direct assessment of brain SBVs in vivo is currently not feasible. Retinal vessels are considered a "mirror" of brain SBVs. In this study, we used optic coherence tomography (OCT)-based measurements to detect changes in retinal blood vessels of ALS patients compared to those of healthy controls. We analysed Spectralis-OCT images of 34 ALS patients and 20 HCs. The inner wall thickness (IWT), outer wall thickness (OWT), and lumen diameter (LD) of retinal vessels were assessed using intensity-based measurements. In addition, the different retinal layers were analysed using automated segmentation software. The correlations between the various retinal layers and clinical parameters [e.g., disease duration and revised ALS functional rating scale (ALS-FRS-R)] were examined. The OWT of retinal vessels was higher in ALS patients than in HCs (p = 0.04). There were no differences in the IWT, LD. ALS patients showed a thinning of the outer nuclear layer (ONL) compared to HCs (median 1.63 vs. 1.77, p = 0.002). The whole retinal thickness negatively correlated with the ALS-...Continue Reading

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Citations

Dec 4, 2019·Journal of Neurology·Andrea CerveróJavier Riancho
Dec 14, 2019·Therapeutic Advances in Chronic Disease·Timothy E YapM Francesca Cordeiro
Dec 17, 2020·Neurological Research and Practice·A AbdelhakH Neugebauer
May 21, 2021·Eye and Brain·Vladislav O SoldatovAlexey V Deykin

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