In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study

Frontiers in Physiology
Wenxu QiYong Wang

Abstract

In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state (3D-CISS) sequence to examine the FM at the cervical internal os zone during pregnancy; 18 pregnant women with one to three longitudinal MRI scans were included in this study. In 14 women, the FM appeared normal and completely intact. In four women, we noted several FM abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the FM ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that improves examination of the FMs.

References

Jun 15, 1979·American Journal of Obstetrics and Gynecology·J P Lavery, C E Miller
Jul 1, 1976·American Journal of Obstetrics and Gynecology·R ArtalJ Stojkov
Mar 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H OxlundN Uldbjerg
Mar 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R HelmigN Uldbjerg
Mar 1, 1997·Fetal Diagnosis and Therapy·J L GrafM R Harrison
Mar 5, 1998·The New England Journal of Medicine·S Parry, J F Strauss
Jun 26, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Roman M SydorakCraig T Albanese
Aug 13, 2003·Fetal Diagnosis and Therapy·R Douglas WilsonN Scott Adzick
Oct 7, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R DevliegerF P H A Vandenbussche
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Michelle L OyenSteven E Calvin
Feb 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Hyagriv N Simhan, Timothy P Canavan
Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
Jul 30, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F M SeveriF Petraglia
Apr 22, 2011·Clinical Obstetrics and Gynecology·Thaddeus P Waters, Brian Mercer
Jan 24, 2012·Reproductive Sciences·Jerome F Strauss
Aug 14, 2013·The Journal of Obstetrics and Gynaecology Research·Derman BaşaranLütfü S Önderoğlu
May 7, 2014·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Yves PatenaudeUNKNOWN Society of Obstetricians and Gynaecologists of Canada
Sep 7, 2016·JAMA : the Journal of the American Medical Association·Joel G RayAlison L Park
Sep 30, 2016·AJP Reports·Carolina BibboJulian N Robinson
Aug 16, 2017·Seminars in Perinatology·Ramkumar Menon, Lauren S Richardson

❮ Previous
Next ❯

Software Mentioned

CISS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.