In vivo assessment of the protection conferred by β-glucans from Pleurotus ostreatus against the harmful effects of acrylamide intake (Part I).

Nutrición hospitalaria
Blanca Rosa Aguilar UscangaJulio Serrano Niño

Abstract

Introduction: acrylamide is formed in food through Maillard's reaction during thermal processing, and has been shown to be neurotoxic in humans, and a possible carcinogen. Studies have shown that β-glucans from Pleurotus ostreatus have diverse biological properties such as antioxidant and anticancer activities. Objective: the aim of this work was to evaluate the protective effect of β-glucans from Pleurotus ostreatus against the harmful effects of acrylamide consumption in mice. Methods: β-glucans were obtained by alkaline-acid hydrolysis of Pleurotus ostreatus, and the content was characterized by liquid chromatography. To evaluate the effect of β-glucans on the expression of glutathione, Balb/c mice were used, and 4 test groups were established. All groups were fed normally, and the groups treated with acrylamide were administered the compound intragastrically at a concentration of 50 g/mL; β-glucans were administered at a concentration of 50 g/mL. Results: mice exposed to acrylamide showed a marked variation in the activity of glutathione enzymes in the liver. Significant differences (p < 0.05) were only found in the expression of glutathione transferase, which was increased almost 3 times in the group treated with β-gluca...Continue Reading

References

May 1, 1976·Journal of General Microbiology·G H Fleet, D J Manners
Jul 1, 1996·Occupational and Environmental Medicine·M MatsuokaH Igisu
Nov 24, 1999·Chemical Research in Toxicology·S C SumnerB I Ghanayem
Jan 24, 2004·International Archives of Occupational and Environmental Health·T SchettgenJ Angerer
Sep 15, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ke CuiM R Ven Murthy
Jun 15, 2005·International Immunopharmacology·Göksel SenerGözde Erkanli
Dec 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M E AwadS A Hassan
Aug 24, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Thanasekaran JayakumarPitchairaj Geraldine
Dec 6, 2011·Annual Review of Food Science and Technology·David R LinebackRichard H Stadler

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