In vivo assessment of two endothelialization approaches on bioprosthetic valves for the treatment of chronic deep venous insufficiency

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jeremy J GlynnMonica T Hinds

Abstract

Chronic deep venous insufficiency is a debilitating disease with limited therapeutic interventions. A bioprosthetic venous valve could not only replace a diseased valve, but has the potential to fully integrate into the patient with a minimally invasive procedure. Previous work with valves constructed from small intestinal submucosa (SIS) showed improvements in patients' symptoms in clinical studies; however, substantial thickening of the implanted valve leaflets also occurred. As endothelial cells are key regulators of vascular homeostasis, their presence on the SIS valves may reduce the observed thickening. This work tested an off-the-shelf approach to capture circulating endothelial cells in vivo using biotinylated antikinase insert domain receptor antibodies in a suspended leaflet ovine model. The antibodies on SIS were oriented to promote cell capture and showed positive binding to endothelial cells in vitro; however, no differences were observed in leaflet thickness in vivo between antibody-modified and unmodified SIS. In an alternative approach, valves were pre-seeded with autologous endothelial cells and tested in vivo. Nearly all the implanted pre-seeded valves were patent and functioning; however, no statistical diffe...Continue Reading

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Citations

Jun 21, 2017·Biomechanics and Modeling in Mechanobiology·Hsiao-Ying Shadow Huang, Jiaqi Lu
Apr 14, 2016·Advanced Healthcare Materials·Jeremy J Glynn, Monica T Hinds
Sep 25, 2020·Tissue Engineering. Part B, Reviews·Alicia Fernández-Colino, Stefan Jockenhoevel

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