In vivo assessments of calcium-regulated parathyroid hormone release in secondary hyperparathyroidism

Kidney International
W G GoodmanI B Salusky

Abstract

In vivo dynamic tests of parathyroid gland function have provided useful information about the secretory behavior of parathyroids in various clinical disorders, but the limitations of this approach must be recognized when applied to studies of parathyroid gland physiology. Set point abnormalities have been documented in vivo both in primary hyperparathyroidism and in familial hypocalciuric hypercalcemia. Such findings are consistent with in vitro results obtained in studies of dispersed parathyroid cells from patients with primary hyperparathyroidism and with recently described alteration in calcium receptor expression in patients with FHH. The assessment of parathyroid gland function in patients with end-stage renal disease presents distinct methodological problems, however, because of marked variation in the degree of parathyroid gland enlargement. Neither the four parameter model originally used to describe set point abnormalities both in vitro and in vivo or alternative approaches to the assessment of PTH secretion in vivo adequately address this important issue. Results from recent in vivo studies of patients with chronic renal failure do not support the view that the set point for calcium-regulated PTH release is abnormal...Continue Reading

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Citations

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T MikiH Morii
Jan 20, 2004·Seminars in Nephrology·William G Goodman
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Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·W G GoodmanI B Salusky
Jun 18, 1999·The American Journal of the Medical Sciences·T Akizawa, M Fukagawa

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