In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa

Turkish Journal of Medical Sciences
Moustafa Fathy, Toshio Nikaido

Abstract

Background/aim: Angiogenesis is imperative in malignant tumor growth. Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis. The aim of this study is to investigate the in vivo molecular mechanism underlying the antitumor properties of Nigella sativa ethanolic extract (NSEE) through its antiangiogenic effect against diethyl nitrosamine (DENA)-induced hepatocarcinogenesis. Materials and methods: Male Wistar rats were divided into 4 groups: normal, NSEE, DENA, and NSEE-DENA groups. Final body weight, hepatosomatic indices, serum AFP, serum vascular endothelial growth factor (VEGF) levels, and liver tissue hepatocyte growth factor ß (HGFß) protein expression were estimated. Liver sections were stained for histological examination. AFP levels with the histological variations were chosen to confirm cancer development. Results: DENA significantly increased liver weight, hepatosomatic indices, serum AFP and VEGF levels, and liver HGFß protein expression and significantly decreased final body weight. These effects were significantly reversed by NSEE. Furthermore, the histopathological changes that appeared in rat livers due to DENA were reduced by NSEE without harmful effects when taken alone. Conclusion...Continue Reading

Citations

Jul 25, 2019·Journal of Biochemical and Molecular Toxicology·Oguzhan TatarIbrahim Hanifi Ozercan
Jun 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Ebrahim M YimerFarooq Anwar
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Moustafa FathyEman M Othman
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eman M OthmanMuhammad Naseem
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Johura AnsaryDanila Cianciosi

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