In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography

Optics Letters
J A IzattA J Welch

Abstract

We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with <50-microm spatial resolution and <0.6-mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications.

References

Nov 1, 1979·Microvascular Research·H D PapenfussF A Treese
Nov 22, 1991·Science·D HuangC A Puliafito
Jun 1, 1995·Optics Letters·X J WangJ S Nelson
Jun 15, 1981·Applied Optics·R Bonner, R Nossal

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Citations

Dec 27, 2013·Mediators of Inflammation·Bartosz L SikorskiDorota Raczynska
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·John O Schenk, Mark E Brezinski
Nov 22, 2008·Journal of Biomedical Optics·Bin RaoZhongping Chen
Mar 10, 2010·Journal of Biomedical Optics·Melissa C SkalaMark W Dewhirst
Mar 10, 2010·Journal of Biomedical Optics·Lingfeng Yu, Zhongping Chen
Mar 10, 2010·Journal of Biomedical Optics·Mamta WankhedeBrian S Sorg
Jun 25, 2013·Microfluidics and Nanofluidics·Salvatore CitoIoanis Katakis
Jun 8, 2011·Archives of Dermatological Research·Thilo GambichlerSarah Terras
May 7, 2011·Analytical and Bioanalytical Chemistry·Sebastian MarschallPeter E Andersen
May 13, 2011·Analytical and Bioanalytical Chemistry·Julia WaltherEdmund Koch
Jun 27, 2009·Annual Review of Neuroscience·Brian A WiltMark J Schnitzer
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Elizabeth M C HillmanRichard M Levenson
Dec 8, 2010·Zeitschrift für medizinische Physik·Adolf Friedrich Fercher
May 17, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Mehreen AdhiJay S Duker
Mar 7, 2009·Current Opinion in Biotechnology·Brett E BoumaGuillermo J Tearney
Feb 14, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jonghwan LeeDavid A Boas
Dec 13, 2006·Progress in Retinal and Eye Research·Mirjam E J van VelthovenMarc D de Smet
Jun 9, 2009·Journal of Biophotonics·Jon Holmes
Jul 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mary E Dickinson
Jun 20, 2012·Journal of Biophotonics·Susan M Daly, Martin J Leahy
Mar 1, 2013·IEEE Transactions on Medical Imaging·Aaron C ChanVivek J Srinivasan
Feb 14, 2008·IEEE Transactions on Bio-medical Engineering·Wei XuJennifer K Barton
Jan 24, 2009·IEEE Transactions on Medical Imaging·Benjamin J VakocBrett E Bouma
Jan 16, 2004·IEEE Transactions on Bio-medical Engineering·Alexander W SchaeferStephen A Boppart
Apr 1, 2000·Gastrointestinal Endoscopy·J Van Dam, J G Fujimoto
Jul 21, 2004·Gastrointestinal Endoscopy Clinics of North America·John M Poneros
Aug 15, 2003·Gastrointestinal Endoscopy Clinics of North America·John M Poneros, Norman S Nishioka
Oct 28, 2015·BioMed Research International·Alex D PechauerYali Jia
Jun 6, 2015·International Ophthalmology·Asima BajwaAshvini K Reddy
Jan 20, 2015·Translational Vision Science & Technology·Elsbeth J T van ZeeburgJohannes F de Boer
Jul 7, 2011·Progress in Retinal and Eye Research·Michael PircherUrsula Schmidt-Erfurth
Apr 8, 2014·Progress in Retinal and Eye Research·Rainer A LeitgebLeopold Schmetterer
Dec 17, 2014·American Journal of Ophthalmology·Masahiro MiuraHiroshi Goto
Nov 25, 2014·Cellular and Molecular Life Sciences : CMLS·Brendan K Huang, Michael A Choma
May 18, 2001·Best Practice & Research. Clinical Gastroenterology·A M Rollins, M V Sivak
Aug 19, 2015·Scientific Reports·Shang WangIrina V Larina
Nov 18, 2005·International Journal of Cardiology·Mark E Brezinski
Sep 1, 2005·Optics Letters·Cameron J PedersenAndrew M Rollins

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