Abstract
We studied the in vivo biomechanical properties of the anterior urethra in a rabbit hypospadias simulation model at long-term followup after urethroplasty. A total of 38, 9-week-old white New Zealand male rabbits were randomized into active treatment and control groups. The active treatment group included hypospadias-like simulation and acute repair (sham, mobilization and advancement, tubularized incised posterior urethral plate). After 23 weeks all groups underwent biomechanical investigation using impedance planimetry. Cross-sectional area pressure measurements during bag distention were conducted at 3 different positions along the urethra, and biomechanical (tension-strain) relations were computed. The biomechanical parameters studied were urethral luminal dimension (cross-sectional area pressure relation) and its deformability to luminal pressure (tension-strain relation). The urethral cross-sectional area was significantly larger in the mobilization and advancement group compared to the tubularized incised plate group (p <0.001), shams and controls at the distal distention site (p <0.05), and other groups at the intermediate distention site (p <0.05). The strain-tension curves were not significantly different between the ...Continue Reading
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Citations
Dec 12, 2012·World Journal of Urology·L E JesusJ L Pippi-Salle
Aug 25, 2011·The Journal of Urology·Bruno LeslieJoão L Pippi Salle
Apr 13, 2019·International Journal of Molecular Sciences·Tariq O AbbasCristian P Pennisi
Aug 31, 2021·Frontiers in Pediatrics·Tariq O AbbasAbdulla Alnaimi