In vivo biomechanical assessment of anterior rabbit urethra after repair of surgically created hypospadias

The Journal of Urology
Marianna LallaTroels Munch Jørgensen

Abstract

We studied the in vivo biomechanical properties of the anterior urethra in a rabbit hypospadias simulation model at long-term followup after urethroplasty. A total of 38, 9-week-old white New Zealand male rabbits were randomized into active treatment and control groups. The active treatment group included hypospadias-like simulation and acute repair (sham, mobilization and advancement, tubularized incised posterior urethral plate). After 23 weeks all groups underwent biomechanical investigation using impedance planimetry. Cross-sectional area pressure measurements during bag distention were conducted at 3 different positions along the urethra, and biomechanical (tension-strain) relations were computed. The biomechanical parameters studied were urethral luminal dimension (cross-sectional area pressure relation) and its deformability to luminal pressure (tension-strain relation). The urethral cross-sectional area was significantly larger in the mobilization and advancement group compared to the tubularized incised plate group (p <0.001), shams and controls at the distal distention site (p <0.05), and other groups at the intermediate distention site (p <0.05). The strain-tension curves were not significantly different between the ...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Urology and Nephrology·P ThindK E Andersson
Jan 1, 1991·Digestive Diseases·H Gregersen, J C Djurhuus
Feb 1, 1994·The Journal of Urology·W Snodgrass
Oct 1, 1996·Scandinavian Journal of Urology and Nephrology·H GregersenJ C Djurhuus
Aug 27, 1998·The Journal of Urology·L S BaskinG R Cunha
May 10, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Peter K Gregersen
Jun 19, 2004·Scandinavian Journal of Urology and Nephrology·H L AndersenJ C Djurhuus
Sep 1, 2007·Diseases of the Colon and Rectum·Inge S AndersenSøren Laurberg

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