In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite

Biomaterials
E VerronJ M Bouler

Abstract

Resorbable calcium phosphate (CaP) biomaterials have demonstrated considerable efficacy in bone reconstructive surgery. Furthermore, bisphosphonates (BPs) are well known anti-resorptive agents largely used in clinical treatments for osteoporosis. An injectable BP-combined CaP matrix has been developed in order to biologically reinforce osteoporotic bone by increasing the bone fraction and improving bone micro-architecture. Our previous in vitro studies have shown that CaP is effective for loading and releasing BPs at doses that can inhibit excessive bone resorption without affecting osteoblasts. In vivo studies in relevant animal models are necessary to explore the effect of our injectable BP-combined biomaterial on femur bone structure by performing three-dimensional microtomography analysis, histological studies and SEM observations. Firstly, in rat model, our BP-combined CaP matrix significantly improved the bone micro-architecture as compared to CaP alone. The implantation of the BP-loaded biomaterial within proximal femurs of osteoporotic ewes led to a significant increase in relative bone content and an improvement of its micro-architecture. These modifications were confirmed by histological and SEM observations, which re...Continue Reading

References

Sep 1, 1992·Bone and Mineral·H M Frost, W S Jee
Sep 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J MeltonB L Riggs
Dec 1, 1991·Bone and Mineral·D N Kalu
Sep 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G JonesJ A Eisman
Feb 14, 1998·The Journal of Bone and Joint Surgery. British Volume·A O RansfordD Pries
Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S P LuckmanM J Rogers
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M KlotzbuecherM Berger
Nov 23, 2000·The New England Journal of Medicine·P KannusI Vuori
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P ChavassieuxP J Meunier
Mar 16, 2001·Expert Opinion on Pharmacotherapy·M R McClung
May 11, 2001·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·P F HeiniP van Landuyt
Apr 12, 2002·Journal of Biomedical Materials Research·I KhairounP Weiss
Jul 4, 2002·Injury·A F Dinah
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Reinhold G ErbenRoger Phipps
May 15, 2003·Disability and Rehabilitation·Romke Van BalenDik F Habbema
Apr 1, 2004·Journal of Comparative Pathology·B I NewtonL D Zardiackas
Aug 4, 2004·Journal of Oral Science·Guizhen JiangAkira Fujii
Sep 28, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Socrates E PapapoulosDesmond E Thompson
Dec 4, 2004·Biomaterials·Solen JosseJean-Michel Bouler
Oct 29, 2005·Journal of Biomedical Materials Research. Part a·Bastian PeterDominique P Pioletti
Dec 6, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Philippe Orcel
Mar 15, 2006·Bone·R G G Russell
Mar 28, 2006·The American Journal of Medicine·Ronald D Emkey, Mark Ettinger
May 9, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Laetitia ObadiaJean Michel Bouler
Feb 20, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A CramerE M Lewiecki
Mar 28, 2007·American Journal of Preventive Medicine·Jesus Ramirez-Valles
May 23, 2007·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·Patricia A QuigleyStephanie Hart-Hughes
Sep 12, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ann CranneyWilliam D Leslie
Nov 14, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V RabendaJ Y Reginster
Apr 12, 2008·Journal of Biomedical Materials Research. Part a·C FaucheuxJ Guicheux
May 29, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Arlene M GallagherTjeerd P van Staa
Oct 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Véronique RabendaJean-Yves Reginster

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Citations

Oct 24, 2012·Journal of Materials Science. Materials in Medicine·Nenad IgnjatovićDragan Uskoković
Apr 26, 2012·Chemical Reviews·Clémence QueffélecBruno Bujoli
Jul 29, 2011·Inorganic Chemistry·Charlotte MellierPascal Janvier
Nov 22, 2011·Tissue Engineering. Part C, Methods·Marco A Lopez-HerediaJohn A Jansen
Jul 24, 2012·Regenerative Medicine·Kevin W-H LoCato T Laurencin
Aug 13, 2013·Journal of Bone and Mineral Metabolism·Ning YangChunli Song
Jan 11, 2014·Drug Delivery·Mohammad FazilJaved Ali
Mar 30, 2013·Expert Opinion on Drug Delivery·Mohammad FazilJaved Ali
Aug 1, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J TanC L Song
Feb 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elisabeth V GigerJean-Christophe Leroux
Jun 20, 2012·Drug Discovery Today·E VerronJ C Scimeca
Feb 27, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ralf OheimPia Pogoda
Jan 1, 2014·Journal of Cellular and Molecular Medicine·Viviana RibeiroMaria Helena Fernandes
Jul 25, 2015·Journal of Orthopaedic Surgery and Research·Carsten W SchlickeweiWolfgang Lehmann
Jun 16, 2015·Acta Biomaterialia·Charlotte MellierBruno Bujoli
Jan 15, 2014·Acta Biomaterialia·D ArcosM Vallet-Regí
Aug 27, 2013·Drug Discovery Today·E Verron, J M Bouler
Sep 15, 2014·Acta Biomaterialia·Laura KyllönenDavid Eglin
Jan 13, 2017·Journal of Tissue Engineering and Regenerative Medicine·Ivana Strazic GeljicJean-Claude Scimeca
Jan 19, 2018·Journal of Functional Biomaterials·Adriana Bigi, Elisa Boanini
Feb 26, 2016·Materials·Elisa BoaniniAdriana Bigi
Apr 2, 2016·Materials·Gianluca TozziMarta Roldo
Jul 5, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Luc Le FournierJohann Clouet
Feb 1, 2020·Biomicrofluidics·Zhijie MaHaiyan Li
Mar 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoyi ChenZhongru Gou
Jun 3, 2017·Journal of Applied Biomaterials & Functional Materials·Adriana Bigi, Elisa Boanini
Feb 2, 2021·Journal of Medicinal Chemistry·Jéssica S BarbosaSusana Santos Braga
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Öznur Demir-Oğuz, Duygu Ege
Oct 8, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Luisa Stella DolciNadia Passerini

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