In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jinfeng LiangThomas Efferth

Abstract

Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. To date, no toxicity or adverse events in SA have been reported, by using routine models (in vivo or in vitro), which are insufficient to predict all aspects of its pharmacological and toxicological actions. In this study, taking advantage of transparent zebrafish larvae (Danio rerio), we evaluated cardiovascular toxicity of SA at doses of 1/10 MNLC, 1/3 MNLC, MNLC and LC10 by yolk sac microinjection. The qualitative and quantitative cardiotoxicity in zebrafish was assessed at 48 h post-SA treatment, using specific phenotypic endpoints: heart rate, heart rhythm, heart malformation, pericardial edema, circulation abnormalities, thrombosis and hemorrhage. The results showed that SA at 1/10 MNLC and above doses could induce obvious cardiac and pericardial malformations, whilst 1/3 MNLC and above doses could induce significant cardiac malfunctions (heart rate and circulation decrease/absence), as compared to untreated or vehicle-treated control groups. Such cardiotoxic manifestations occurred in more than 50% to 100% of all ...Continue Reading

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Citations

Nov 22, 2016·International Journal of Molecular Sciences·Magda Dubińska-MagieraKrzysztof Jagla
Jan 25, 2020·Dose-response : a Publication of International Hormesis Society·Chuanrui ZhengThomas Efferth
Jan 15, 2021·Journal of Applied Toxicology : JAT·Zheng-Cai DuJia-Gang Deng
Jan 30, 2020·Toxicology Reports·Tamanna KabirMohammad Jakir Hosen
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Avez SharipovJamoliddin Razzokov
Jan 29, 2022·Chinese Journal of Integrative Medicine·Rong-Rong WangLan Li

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