In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells.

PLoS Pathogens
Joseph K WongSatya Dandekar

Abstract

The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamics during antiretroviral treatment of simian immunodeficiency virus (SIV) infected rhesus macaques following CD8+ T-cell depletion to test the importance of adaptive cytotoxic effects in clearance of cells productively infected with SIV. As previously described, plasma viral load (VL) increased following CD8+ T-cell depletion and was proportional to the magnitude of CD8+ T-cell depletion in the GALT, confirming a direct relationship between CD8+ T-cell loss and viral replication. Surprisingly, first phase plasma virus decay following administration of antiretroviral drugs was not slower in CD8+ T-cell depleted animals compared with controls indicating that the short lifespan of the average productively infected cell is not a reflection of cytotoxic T-lymphocyte (CTL) killing. Our findings support a dominant role for non-cytotoxic effects of CD8+ T-cells on control of pathogenic lentiviral infection and suggest that cytotoxic effects, if present, are limited to early, pre-productive stages of the viral life cycle. These observations hav...Continue Reading

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Apr 5, 2014·PLoS Computational Biology·Marjet ElemansBecca Asquith
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Datasets Mentioned

BETA
GU366223
GU366660

Methods Mentioned

BETA
biopsy
PCR
density gradient centrifugation
PCRs
FACS

Software Mentioned

Se
clustalW
PHYLIP
Synonymous - Nonsynonymous Analysis Program ( SNAP )
Dnadist
Sequencher

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