PMID: 8456987Mar 1, 1993Paper

In vivo cerebrovascular reactivity in Wistar and Fischer 344 rat strains during aging

The American Journal of Physiology
I LartaudC Capdeville-Atkinson

Abstract

Basal cerebral blood flow (CBF) and CBF regulation after hypercapnia and hypotensive hemorrhage were investigated using H2 clearance in the frontal cortex of awake 2-, 14-, or 23-mo-old Wistar or Fischer 344 rats. Basal CBF decreased in old Wistar but not in mature Wistar (old 64.4 +/- 2.8, mature 87.6 +/- 2.6, young 79.6 +/- 2.2 ml.min-1 x 100 g-1) or in old Fischer 344 (old 71.9 +/- 2.9, young 73.3 +/- 1.6 ml.min-1 x 100 g-1) rats. Cerebrovascular reactivity to hypercapnia decreased in mature and old Wistar (old 2.1 +/- 0.3, mature 3.1 +/- 0.7, young 7.0 +/- 2.1 ml.min-1 x 100 g-1 x mmHg-1) but not in old Fischer 344 rats (old 4.6 +/- 1.4, young 4.9 +/- 0.9 ml.min-1 x 100 g-1 x mmHg-1). The lower limit of CBF autoregulation increased by 20 mmHg during maturation and/or aging in the two strains. Because blood gases and pH evolved similarly in both strains, we postulate that differences in cerebrovascular structure and/or function explain the differences in CBF regulation in the older representatives of the two strains.

Citations

Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·O RégrignyJ M Chillon
Jun 24, 2003·Journal of Applied Physiology·Greg G Geary, John N Buchholz
May 31, 2018·Scientific Reports·Mohammad MoeiniFrédéric Lesage
Sep 14, 2004·Journal of Applied Physiology·Jorge M SerradorLewis A Lipsitz
May 22, 2010·Journal of Applied Physiology·Nisreen Mansour Omar, Janice M Marshall

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