In Vivo Characterization and Quantification of Neurofibrillary Tau PET Radioligand 18 F-MK-6240 in Humans from Alzheimer Disease Dementia to Young Controls

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Tobey J BetthauserBradley T Christian

Abstract

Tau PET imaging has potential for elucidating changes in the deposition of neuropathological tau aggregates that are occurring during the progression of Alzheimer disease (AD). This work investigates in vivo kinetics, quantification strategies, and imaging characteristics of a novel tau PET radioligand 18F-MK-6240 in humans. Methods: Fifty-one individuals ranging from cognitively normal young controls to persons with dementia underwent T1-weighted MRI as well as 11C-PiB and 18F-MK-6240 PET imaging. PET data were coregistered to the MRI, and time-activity curves were extracted from regions of interest to assess 18F-MK-6240 kinetics. The pons and inferior cerebellum were investigated as potential reference regions. Reference tissue methods (Logan graphical analysis [LGA] and multilinear reference tissue method [MRTM2]) were investigated for quantification of 18F-MK-6240 distribution volume ratios (DVRs) in a subset of 19 participants. Stability of DVR methods was evaluated using truncated scan durations. SUV ratio (SUVR) estimates were compared with DVR estimates to determine the optimal timing window for SUVR analysis. Parametric SUVR images were used to identify regions of potential off-target binding and to compare binding pat...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganD L Alexoff
Sep 16, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masanori IchiseRichard E Carson
Jun 18, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bradley T ChristianCharles A Mistretta
Oct 18, 2011·Journal of Neuropathology and Experimental Neurology·Heiko BraakKelly Del Tredici
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
Nov 26, 2013·Neurobiology of Aging·Sterling C JohnsonMark A Sager
Jul 3, 2015·Acta Neuropathologica Communications·Laetitia LemoineAgneta Nordberg
Oct 1, 2015·Nuclear Medicine and Biology·Hiroki HashimotoMing-Rong Zhang
Oct 28, 2015·Annals of Neurology·Keith A JohnsonReisa Sperling
Jan 23, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·My JonassonMark Lubberink
May 14, 2016·Science Translational Medicine·Matthew R BrierBeau M Ances
May 28, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eric D HostetlerJeffrey L Evelhoch
Jun 12, 2016·Brain : a Journal of Neurology·Brian A GordonTammie L S Benzinger
Sep 24, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dustin W WootenMarc D Normandin
Oct 30, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackRonald C Petersen
Dec 19, 2016·Seminars in Nuclear Medicine·Victor L VillemagneChristopher C Rowe
Apr 1, 2017·Alzheimer's Research & Therapy·Kok Pin NgPedro Rosa-Neto
Aug 23, 2017·Seminars in Nuclear Medicine·Chester A MathisWilliam E Klunk
Oct 17, 2017·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Tobey J BetthauserBradley T Christian
Oct 20, 2017·Neurology·Michel J GrotheUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 20, 2017·JAMA Neurology·Ingrid S van MaurikUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 12, 2017·Brain : a Journal of Neurology·Val J LoweClifford R Jack
Jan 13, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sterling C JohnsonMark A Sager

❮ Previous
Next ❯

Citations

Feb 16, 2019·Acta Neuropathologica Communications·Santosh JadhavNorbert Zilka
Mar 29, 2019·European Journal of Nuclear Medicine and Molecular Imaging·N Arul MuruganAgneta Nordberg
Jun 7, 2019·Current Neurology and Neuroscience Reports·Yi Ting Wang, Paul Edison
Oct 16, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Ruben SmithOskar Hansson
Dec 31, 2019·Brain : a Journal of Neurology·Tobey J BetthauserSterling C Johnson
Sep 22, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Stuart P McCluskeyOliver Howes
May 22, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Michel KooleArie Struyk
Feb 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bright Chukwunwike UzuegbunamBehrooz Hooshyar Yousefi
Apr 7, 2020·Molecular Psychiatry·Henrik Zetterberg, Barbara B Bendlin
Jul 17, 2020·Brain : a Journal of Neurology·Tharick A PascoalPedro Rosa-Neto
Sep 8, 2019·Japanese Journal of Radiology·Hiroshi MatsudaNoriko Sato
Mar 27, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Rebecca L KoscikSterling C Johnson
Apr 7, 2020·Journal of Alzheimer's Disease : JAD·José A LuchsingerAdam M Brickman
Jun 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Elizabeth C MorminoFrederick T Chin
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarah K YeoMitchell S Albert
Aug 28, 2018·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Nobuyuki OkamuraYukitsuka Kudo
Jul 2, 2019·The American Journal of Psychiatry·Sterling C Johnson, Sanjay Asthana
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Solveig TiepoltOsama Sabri
Apr 23, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Leonie BeyerMatthias Brendel
Mar 13, 2019·Acta Neuropathologica Communications·Cinthya AgueroTeresa Gomez-Isla
Jun 15, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Mark E SchmidtHartmuth Kolb
Sep 22, 2020·Brain Communications·Sean TanabeRobert D Sanders
Jul 25, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas J GuehlMarc D Normandin
Jan 13, 2019·Molecular Psychiatry·Antoine LeuzyAgneta Nordberg
Nov 13, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cristian SalinasLaurent Martarello
Nov 4, 2020·Brain : a Journal of Neurology·David N Soleimani-MeigooniGil D Rabinovici
Nov 24, 2020·Molecular Neurodegeneration·L LemoineA C Granholm
Jun 27, 2019·Progress in Neurobiology·Thomas W RöslerGünter U Höglinger
Nov 19, 2019·Biological Psychiatry·Thomas VogelsMichael Schöll
Jan 14, 2021·Brain : a Journal of Neurology·Ruben SmithOskar Hansson
Feb 17, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Gérard N BischofAlexander Drzezga
Mar 2, 2021·Journal of Alzheimer's Disease : JAD·Julia KleinWilliam C Kreisl
Jan 28, 2021·Seminars in Nuclear Medicine·Aren van WaardeRudi A J O Dierckx
Mar 25, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ming-Kai ChenRichard E Carson
Dec 24, 2020·Seminars in Nuclear Medicine·Leonie Beyer, Matthias Brendel
Oct 31, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Hyunjung Kim, Yearn Seong Choe
Apr 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael L AloscoJesse Mez
Apr 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Adam J Schwarz
Apr 25, 2021·Neurobiology of Aging·Priya PaltaJosé A Luchsinger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Tobey J BetthauserBradley T Christian
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Talakad G LohithArie Struyk
Alzheimer's Research & Therapy
Tharick A PascoalPedro Rosa-Neto
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Sergey ShcherbininMark A Mintun
© 2022 Meta ULC. All rights reserved