In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers

Viruses
Yao LuYan Zhou

Abstract

Highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H7N9 viruses pose a severe threat to public health through zoonotic infection, causing severe respiratory disease in humans. While HPAI H5N1 human infections have typically been reported in Asian countries, avian H7N9 human infections have been reported mainly in China. However, Canada reported a case of fatal human infection by the HPAI H5N1 virus in 2014, and two cases of human illness associated with avian H7N9 virus infection in 2015. While the genomes of the causative viruses A/Alberta/01/2014 (H5N1) (AB14 (H5N1)) and A/British Columbia/1/2015 (H7N9) (BC15 (H7N9)) are reported, the isolates had not been evaluated for their pathogenicity in animal models. In this study, we characterized the pathogenicity of AB14 (H5N1) and BC15 (H7N9) and found that both strain isolates are highly lethal in mice. AB14 (H5N1) caused systemic viral infection and erratic proinflammatory cytokine gene expression in different organs. In contrast, BC15 (H7N9) replicated efficiently only in the respiratory tract, and was a potent inducer for proinflammatory cytokine genes in the lungs. Our study provides experimental evidence to complement the specific human ca...Continue Reading

References

Feb 25, 2000·Allergy·G Tau, P Rothman
Jul 13, 2000·Microscopy Research and Technique·H T Idriss, J H Naismith
Jan 18, 2008·The New England Journal of Medicine·UNKNOWN Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian InfTimothy M Uyeki
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin N CouperEleanor M Riley
Aug 28, 2010·The Journal of General Virology·Thomas RoweDavid J Kelvin
May 28, 2011·Immunity·Yueh-Ming Loo, Michael Gale
Apr 13, 2013·The New England Journal of Medicine·Rongbao GaoYuelong Shu
Aug 31, 2013·The Journal of Infectious Diseases·Ying ChiMinghao Zhou
Apr 24, 2014·Emerging Infectious Diseases·Kanti PabbarajuGraham A Tipples
Aug 26, 2014·Emerging Infectious Diseases·Sebastian Maurer-StrohTim F Booth
Sep 12, 2014·Journal of Virology·Victoria A MeliopoulosStacey Schultz-Cherry
Dec 23, 2015·Emerging Infectious Diseases·Danuta M SkowronskiYan Li
Feb 26, 2016·Journal of Virology·Jessica A BelserTerrence M Tumpey
Dec 17, 2017·Immunological Reviews·Gilles Kaplanski
Feb 16, 2018·Frontiers in Immunology·Helen T GrovesJohn S Tregoning
Feb 21, 2018·The Journal of General Virology·Leina B SaitoKatharine E Magor
Jun 30, 2018·Nature Reviews. Disease Primers·Florian KrammerAdolfo García-Sastre
Aug 12, 2018·Nature Communications·GuanQun LiuYan Zhou
Oct 12, 2018·Journal of Virology·Xiangjie SunTaronna R Maines

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.