In vivo characterization of pancreatic and lymph node tissue by using EUS spectrum analysis: a validation study.

Gastrointestinal Endoscopy
Ronald E KumonCheri X Deng

Abstract

Quantitative spectral analysis of the radiofrequency (RF) signals that underlie grayscale EUS images can be used to provide additional, objective information about tissue state. Our purpose was to validate RF spectral analysis as a method to distinguish between (1) benign and malignant lymph nodes and (2) normal pancreas, chronic pancreatitis, and pancreatic cancer. A prospective validation study of eligible patients was conducted to compare with pilot study RF data. Forty-three patients underwent EUS of the esophagus, stomach, pancreas, and surrounding intra-abdominal and mediastinal lymph nodes (19 from a previous pilot study and 24 additional patients). Midband fit, slope, intercept, and correlation coefficient from a linear regression of the calibrated RF power spectra were determined. Discriminant analysis of mean pilot-study parameters was then performed to classify validation-study parameters. For benign versus malignant lymph nodes, midband fit and intercept (both with t test P < .058) provided classification with 67% accuracy and area under the receiver operating curve (AUC) of 0.86. For diseased versus normal pancreas, midband fit and correlation coefficient (both with analysis of variance P < .001) provided 93% accur...Continue Reading

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Citations

Jan 9, 2016·Cancer Letters·Darci M FinkMichael A Hollingsworth
Mar 8, 2011·Ultrasound in Medicine & Biology·Ronald E KumonXueding Wang
Apr 18, 2017·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Sep 25, 2019·Annals of Biomedical Engineering·Grace G BushnellLonnie D Shea

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