PMID: 8961172Nov 1, 1996Paper

In-vivo clearance study of vancomycin in rats

The Journal of Pharmacy and Pharmacology
T NakamuraKen-ichi Inui

Abstract

The renal handling of vancomycin in rats and the effects of various drugs (probenecid, cimetidine and quinidine) on urinary excretion of the antibiotic were investigated by in-vivo clearance. The vancomycin-to-inulin excretion ratio (ER) was greater than unity at various infusion rates of vancomycin. Quinidine, co-administered with vancomycin, significantly decreased the total, renal and net secretory clearance of the antibiotic. Cimetidine also decreased, though not significantly, the secretory clearance of vancomycin by about 20%, but probenecid did not. These results suggested that vancomycin is secreted in renal tubules in rats, and that quinidine decreases the total clearance of vancomycin partly by inhibiting its tubular secretion in the kidney.

References

Jun 1, 1978·Annals of Internal Medicine·F V Cook, W E Farrar
Apr 1, 1975·Acta Medica Scandinavica·H E NielsenP E Skov
May 1, 1990·Antimicrobial Agents and Chemotherapy·M J RybakC K Svensson
May 1, 1988·Clinical Pharmacology and Therapeutics·T A GolperW M Bennett
Jun 1, 1988·Antimicrobial Agents and Chemotherapy·K A RodvoldL J Riff
Apr 1, 1983·Journal of Pharmaceutical Sciences·A KamiyaR Hori
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Oct 1, 1993·Physiological Reviews·J B Pritchard, D S Miller
Mar 14, 1993·Biochimica Et Biophysica Acta·T KatsuraR Hori

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Citations

Feb 1, 1997·The Journal of Pharmacy and Pharmacology·T NakamuraK Inui
Jul 27, 2011·Antimicrobial Agents and Chemotherapy·Krishna MuppidiAndrew S Pumerantz
Apr 14, 2012·ISRN Pharmaceutics·Krishna MuppidiGuru Betageri
Sep 2, 1998·Journal of Pharmaceutical Sciences·M KusamaT Iga
Oct 28, 2015·BioMed Research International·Blanca HumanesAlberto Lázaro
Jun 21, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Murali SubramanianSandhya Mandlekar
Dec 27, 2007·Drug Metabolism and Pharmacokinetics·Naoko HodoshimaKen-Ichi Inui
Dec 7, 2010·International Journal of Antimicrobial Agents·Annie Wong-BeringerPaul Beringer
Apr 11, 2000·The Journal of Pharmacy and Pharmacology·T TakuboH Ogata
Apr 27, 1999·The Journal of Pharmacy and Pharmacology·T NakamuraK I Inui
May 1, 2018·Nephron·Juan Carlos Q VelezGautam M Phadke
Sep 21, 2018·The Journal of Bone and Joint Surgery. American Volume·Fred A SweetRyan K Dahlberg
Jan 6, 2017·Journal of the American Society of Nephrology : JASN·Yoshihisa HoriAkihiko Saito
Mar 15, 2019·Experimental and Therapeutic Medicine·Liping WangChanghui Wang

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