PMID: 6413125Jul 1, 1983Paper

In vivo collagen synthesis and deposition in fibrotic and regenerating rat livers

Collagen and Related Research
M RojkindJ Cordero-Hernández

Abstract

The content of liver collagen increases during regeneration posthepatectomy as well as during scar formation after chronic administration of CCl4. However, while in the former system restitution at integrum of the liver is obtained and a normal ratio of connective tissue to cellular elements is established, in the later condition homeostasis is lost and an absolute increase in connective tissue takes place. Therefore, it was important to determine if this difference was associated with differences in the amount and types of collagen produced and deposited in vivo. In this communication we describe experiments performed to determine the amount of collagen types I, III and V present in the connective tissues prepared from control and experimental animals, and to measure the extent of radioactivity in each collagen type after an in vivo pulse with tritiated proline. Our results showed that 5 days post-hepatectomy the net collagen content per g of fresh liver decreased to 50% of control values, the predominant collagen was type I, and the ratio of type I/III collagen was increased as compared to normal liver; in addition, a relative increase in type V collagen (23.6%) as compared to control animals (6.6%) was also seen. At 11 days ...Continue Reading

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Citations

Jan 1, 1985·Collagen and Related Research·M J Barnes
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·A Martinez-Hernandez, P S Amenta
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·A Martinez-Hernandez, P S Amenta
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